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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.
The International journal of developmental biology, 1995An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the ...
J. D. Penner +6 more
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Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis
Mechanisms of Development, 1994The cDNAs encoding the zebrafish homologs of retinoic acid receptor alpha(zRAR alpha) and gamma (zRAR gamma) were isolated and their expression studied in normal and retinoic acid (RA) treated embryos. Expression boundaries in the central nervous system are clearly different from those observed in the mouse, which can only partly be explained by ...
Gerard B.L.J. van der Lans +6 more
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Is 9-Cis-Retinoic Acid the Endogenous Ligand for the Retinoic Acid-X Receptor?
Nutrition Reviews, 2006Specific proteins in the nucleus act as transcription factors upon activation through binding of small molecules (all-trans-retinoic acid, thyroid hormone, vitamin D, and others). The activated (liganded) receptors bind to specific DNA elements as heterodimers, each in combination with the retinoic acid-X receptor (RXR).
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Evolution of the retinoic acid receptor
2014L’acide rétinoïque (AR) est un morphogène dérivé de la vitamine A qui contrôle des processus clés au niveau cellulaire et pendant le développement embryonnaire des chordés. Chez les vertébrés les principaux acteurs de la voie de signalisation de l’AR sont les récepteurs de l’acide rétinoïque (RAR) et les récepteurs des x rétinoïdes (RXR).
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EXPRESSION OF A RETINOIC ACID-RECEPTOR GENE IS REGULATED BY RETINOIC ACID ITSELF
Nutrition Reviews, 2009openaire +2 more sources