Results 251 to 260 of about 62,881 (303)
Transcriptional Activities of Retinoic Acid Receptors
, 2005 Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid ...
Lefebvre, P. +5 more
openaire +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
RETINOIC ACID RECEPTORS AND CANCERS
Annual Review of Nutrition, 2004▪ Abstract Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
Dianne Robert, Soprano +2 more
exaly +3 more sources
Retinoids, Retinoic Acid Receptors, and Cancer
Annual Review of Pathology: Mechanisms of Disease, 2011 Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may ...
Xiao-Han, Tang, Lorraine J, Gudas
openaire +3 more sources
Retinoic acid and retinoic acid receptors in development
Molecular Neurobiology, 1995The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family,
H M, Sucov, R M, Evans
openaire +2 more sources
Retinoic acid and retinoic acid receptors in craniofacial development
Seminars in Cell & Developmental Biology, 1997Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
P, Brickell, P, Thorogood
openaire +2 more sources
Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
2014Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Gutierrez-Mazariegos, Juliana +2 more
openaire +3 more sources
History of Retinoic Acid Receptors
2014The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Doris M, Benbrook +3 more
openaire +2 more sources
Retinoic Acid Receptors in Hematopoiesis
1996Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
S J, Collins, S, Tsai, I, Bernstein
openaire +2 more sources
Chronicle of a discovery: the retinoic acid receptor
Journal of Molecular Endocrinology, 2022The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biology and steroid receptors. This stunning breakthrough triggered a cascade of studies to deconstruct the roles played by the RAR and its natural and synthetic ligands in embryonic development, skin, growth,
Vincent Giguère, Ronald M Evans
openaire +2 more sources