Results 271 to 280 of about 62,881 (303)
Some of the next articles are maybe not open access.
Developmental roles of the retinoic acid receptors
The Journal of Steroid Biochemistry and Molecular Biology, 1995Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David +8 more
openaire +4 more sources
2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
openaire +1 more source
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
openaire +1 more source
Nouvelle revue francaise d'hematologie, 1990
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
H, de Thé, P, Tiollais, A, Dejean
openaire +1 more source
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
H, de Thé, P, Tiollais, A, Dejean
openaire +1 more source
Retinoic Acid Receptor Alpha Amplifications and Retinoic Acid Sensitivity in Breast Cancers
Clinical Breast Cancer, 2013Molecular segmentation of breast cancer allows identification of small groups of patients who present high sensitivity to targeted agents. A patient, with chemo- and trastuzumab-resistant HER2-overexpressing breast cancer, who presented concomitant acute promyelocytic leukemia, showed a response in her breast lesions to retinoic acid, arsenic, and ...
S. Alsafadi +13 more
openaire +3 more sources
Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
Molecular and Cellular Endocrinology, 2012The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through the activation of cognate nuclear receptors, RARs, which work as ligand dependent regulators of transcription. In vitro studies revealed how RARs control gene expression at the molecular level and now it appears that it is fine-tuned by a phosphorylation code ...
Samarut, Eric, Rochette-Egly, Cécile
openaire +3 more sources
Retinoic acid receptors, hematopoiesis and leukemogenesis
Current Opinion in Hematology, 2008All-trans retinoic acid therapy of acute promyelocytic leukemia represents the most successful example of differentiation-induction therapy in clinical oncology. However, acute promyelocytic leukemia represents only a small minority (10-15%) of the myeloid leukemias.
openaire +2 more sources
Mechanisms of transactivation by retinoic acid receptors
BioEssays, 1993AbstractRetinoids play an important role in development and differentiation(1,2). Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ),Abbreviations. RAR: retinoic acid receptor; RXR: retinoid X receptor; T3:thyroid hormone receptor; VD3R: vitamin D3 receptor; PPAR: peroxisome proliferator activated receptor; EcR ...
openaire +2 more sources