Results 261 to 270 of about 62,881 (303)
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Retinoic acid and its receptors
The American Journal of Surgery, 1993Retinoic acid (RA)--the active metabolite of vitamin A--and its analogues have pleiotropic effects on growth, differentiation, proliferation, and development. RA, and its analogues, determine embryonic pattern formation and inhibit tumor growth; however, they are also teratogens.
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Altered retinoic acid receptors
The FASEB Journal, 1996Structurally and functionally altered retinoic acid receptors have been associated with rare human neoplasms: acute promyelocytic leukemia and hepatocellular carcinoma. Whereas the ret‐ inoic acid receptor β (RARβ) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RARα fusion to the ...
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European Journal of Cancer, 1995 Retinoic acid has considerable potential for the chemoprevention and chemotherapy of cancer. Neuroblastoma cells differentiate in response to retinoic acid in vitro, an observation that has led to clinical trials using either the 13-cis or all-trans ...
Penny E Lovat +2 more
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Retinoic acid receptors at 35 years
Journal of Molecular Endocrinology, 2022For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched extensive molecular,
Martin Petkovich, Pierre Chambon
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1992
Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System
Annual Review of Immunology, 2016Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity.
Alexandre, Larange, Hilde, Cheroutre
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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors
The International Journal of Developmental Biology, 1995An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the ...
H, Jiang +6 more
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1995
Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Identification of a receptor for the morphogen retinoic acid
Nature, 1987Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
V, Giguere +3 more
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2015
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
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