Results 51 to 60 of about 105,063 (283)
The Corepressor CTBP2 Is a Coactivator of Retinoic Acid Receptor/Retinoid X Receptor in Retinoic Acid Signaling [PDF]
Molecular and Cellular Biology, 2013 Retinoids play key roles in development, differentiation, and homeostasis through regulation of specific target genes by the retinoic acid receptor/retinoid X receptor (RAR/RXR) nuclear receptor complex. Corepressors and coactivators contribute to its transcriptional control by creating the appropriate chromatin environment, but the precise composition
Lorenza Mittempergher +8 more
openaire +3 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. [PDF]
PLoS Genetics, 2013 Normal embryonic development and tissue homeostasis require precise levels of retinoic acid (RA) signaling. Despite the importance of appropriate embryonic RA signaling levels, the mechanisms underlying congenital defects due to perturbations of RA ...
Enrico D'Aniello +4 more
doaj +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
Endocrine Regulations, 2016 Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR)
Macejova Dana, Toporova L., Brtko J.
doaj +1 more source
BMC Genomics, 2007 Background Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated ...
Wang Tian-Tian +3 more
doaj +1 more source
Retinoids: Mechanisms of Action in Neuronal Cell Fate Acquisition
Life, 2023 Neuronal differentiation has been shown to be directed by retinoid action during embryo development and has been exploited in various in vitro cell differentiation systems.
Aysis Maria Koshy +1 more
doaj +1 more source
The Genetic Role of Retinoic Acid Receptors in Embryonic Development: Study of Genetic Mutations in Retinoic Acid Receptors, Resulting in Tissue Abnormalities [PDF]
, 2007 Retinoic acid (RA) is a vitamin A derivative that exerts profound influences in vertebrate development and physiology. All-trans RA and 9-cis RA, are important regulators of embryonic development, cellular activity and tissue homeostasis.
Ghaedi, Kamran. +2 more
core
Association of retinoic acid receptor genes with meningomyelocele. [PDF]
, 2010 BACKGROUND: Neural tube defects (NTDs) occur in as many as 0.5-2 per 1000 live births in the United States. One of the most common and severe neural tube defects is meningomyelocele (MM) resulting from failed closure of the caudal end of the neural tube.
Au, Kit Sing +6 more
core +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source