Results 71 to 80 of about 62,881 (303)

Retinoic acid receptors in acute myeloid leukemia therapy

, 2019
Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and RXRs) are ligand-dependent transcription factors.
John S. Welch, Orsola di Martino, Martino, Orsola di, Welch, John S   +3 more
core   +2 more sources

Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis

Frontiers in Immunology, 2018
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the ...
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin   +12 more
doaj   +1 more source

Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor. [PDF]

PLoS ONE, 2016
Esophageal squamous cell carcinoma (ESCC) is the predominant pathotype of esophageal carcinoma (EC) in China, especially in Henan province, with poor prognosis and limited 5-year survival rate.
Qingyuan Yang, Rui Wang, Weifan Xiao, Fenyong Sun, Hong Yuan, Qiuhui Pan   +5 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

The Corepressor CTBP2 Is a Coactivator of Retinoic Acid Receptor/Retinoid X Receptor in Retinoic Acid Signaling [PDF]

Molecular and Cellular Biology, 2013
Retinoids play key roles in development, differentiation, and homeostasis through regulation of specific target genes by the retinoic acid receptor/retinoid X receptor (RAR/RXR) nuclear receptor complex. Corepressors and coactivators contribute to its transcriptional control by creating the appropriate chromatin environment, but the precise composition
Prashanth Kumar, Bajpe, Guus J J E, Heynen, Lorenza, Mittempergher, Wipawadee, Grernrum, Iris A, de Rink, Wouter, Nijkamp, Roderick L, Beijersbergen, Rene, Bernards, Sidong, Huang   +8 more
openaire   +2 more sources

13-cis Retinoic Acid Exerts its Specific Activity on Human Sebocytes through Selective Intracellular Isomerization to All-trans Retinoic Acid and Binding to Retinoid Acid Receptors

, 2000
Despite its potent biologic effect on human sebocytes, 13-cis retinoic acid exhibits low binding affinity for cellular retinoic acid binding proteins and nuclear retinoid receptors.
Merk, Hans, Orfanos, Constantin E., Schröder, Mandy, Tsukada, Miki, Chandraratna, Roshantha A. S., Roos, Thomas C., Reichert, Uwe, Zouboulis, Christos C., Chandraratna, Roshantha A.S., Merk, Hans F.   +9 more
core   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

, 2015
All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we have analyzed the phenotypes of mice lacking, in spermatogonia, all rexinoid receptors (RXRA, RXRB
Aurore Gely-Pernot (802378), Marius Teletin, Marius Teletin (802380), Nadège Vernet, Vernet, Nadege, Benoit, Gérard, Féret, Betty, Dennefeld, Christine, Mark, Manuel, Norbert B. Ghyselinck (107799), Betty Féret, Mathilde Raverdeau (802379), Christine Dennefeld, Christine Dennefeld (802382), Manuel Mark, Gérard Benoit (265726), Norbert B Ghyselinck, Mathilde Raverdeau, Manuel Mark (107795), Gérard Benoit, Muriel Klopfenstein (107793), Klopfenstein, Muriel, Muriel Klopfenstein, Gely-Pernot, Aurore, Ghyselinck, Norbert B, Betty Féret (802381), Raverdeau, Mathilde, Teletin, Marius, Davidson, Irwin, Nadège Vernet (589562), Aurore Gely-Pernot, Irwin Davidson, Irwin Davidson (518811)   +32 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters

, 2008
The nuclear retinoic acid (RA) receptor alpha (RARα) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynamic interactions with coregulators, which are coordinated by
Christine Ferry, Hughes de The, Annie Bauer, Vanessa Duong, Cecile Rochette-Egly, Nathalie Bruck, Dominique Vitoux   +6 more
core