Results 111 to 120 of about 620,080 (291)

Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors [PDF]

, 2018
Under homeostatic conditions the release of self-RNA from dying cells does not promote inflammation. However, following injury or inflammatory skin diseases such as psoriasis and rosacea, expression of the cathelicidin antimicrobial peptide LL37 breaks ...
Gerard C. L. Wong, Wong, Gerard CL, Richard L. Gallo, Ernest Y Lee, Toshiya Takahashi, Kulkarni, Nikhil Nitin, Takahashi, Toshiya, Lee, Ernest Y, Nikhil Nitin Kulkarni, Gallo, Richard L, Ling-juan Zhang, Zhang, Ling-juan   +11 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Reciprocal upregulation of scavenger receptors complicates interpretation of nanoparticle uptake in non-phagocytic cells [PDF]

, 2017
Nanoparticles have great potential as drug delivery vehicles or as imaging agents for treatment and diagnosis of various diseases. It is therefore crucial to understand how nanoparticles are taken up by cells, both phagocytic and non-phagocytic.
Rong Miao, Christoffer Åberg, Prapainop, Kanlaya, Dawson, Kenneth A, Åberg, Christoffer; id_orcid, Anna Salvati, Kenneth A. Dawson, Miao, Rong, Kanlaya Prapainop, Åberg, Christoffer, Salvati, Anna   +10 more
core   +2 more sources

Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes

Advanced Science, EarlyView.
A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Subhankar Pradhan, Arko Saha, Bholanath Maity, Sayan Dutta, Luigi Cavallo, Basker Sundararaju   +5 more
wiley   +1 more source

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease

Mediators of Inflammation, 2013
It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer’s disease. However, it is unknown how these cells initiate the response that
Francisca Cornejo, Rommy von Bernhardi
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Human Monocyte Scavenger Receptors Are Pattern Recognition Receptors for (1→3)-β-D-Glucans

, 2002
Glucans are cell wall constituents of fungi and bacteria that bind to pattern recognition receptors and modulate innate immunity, in part, by macrophage activation.
Kelley, Jim L., Williams, David L., Kogan, Grigorij, Ensley, Harry E., Rice, Peter J., William Browder, I., Kalbfleisch, John H.   +6 more
core   +1 more source

CD36, a scavenger receptor implicated in atherosclerosis [PDF]

Experimental & Molecular Medicine, 2014
CD36 is a membrane glycoprotein that is present on various types of cells, including monocytes, macrophages, microvascular endothelial cells, adipocytes and platelets. Macrophage CD36 participates in atherosclerotic arterial lesion formation through its interaction with oxidized low-density lipoprotein (oxLDL), which triggers signaling cascades for ...
openaire   +2 more sources

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1

MicrobiologyOpen, 2019
The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz, Melinda A. Engevik, Zhongcheng Shi, Anne Hall, Beatrice Herrmann, Bhanu P. Ganesh, Angela Major, Anthony Haag, Yuko Mori‐Akiyama, James Versalovic   +9 more
doaj   +1 more source