Results 161 to 170 of about 620,080 (291)

Dietary, Nutrient, and Supramolecular Nanofiber Modulation of the Liver Sinusoidal Clearance System in Metabolic Diseases and Aging. [PDF]

Biomedicines
Pokharel B, Kulkarni A, Drager R, Atta Muhammad F, Ziouzenkova O.   +4 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells. [PDF]

Cells
Pradhan-Sundd T, Branchford B, Beckman J.   +2 more
europepmc   +1 more source

Facet‐Dependent Activity of Fe3S4 Crystal in Peroxydisulfate Activation for Organic Pollutants Degradation

Advanced Science, EarlyView.
Fe3S4 crystal with the exposed [001] facet exhibits higher catalytic activity for activating peroxydisulfate (PDS) to degrade clothianidin (CLO), which can be attributed to the dissolved Fe‐induced homogeneous catalytic process; while Fe3S4 crystal with the exposed [1‐21] facet exhibits excellent catalytic stability and durability, thereby boosting the
Jiaqu Tan, Min Yu, Jinfeng Wang, Dongya Li, Fan Yang, Yulong Zhang, Xueming Lin   +6 more
wiley   +1 more source

Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies. [PDF]

Mol Biomed
Yan M, Cui Y, Xiang Q.
europepmc   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Molecular and spatial specialization of lung interstitial macrophage subsets: beyond chemokines. [PDF]

Front Immunol
Li X, Jakubzick CV.
europepmc   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

The EV-mitochondrial outsourcing network as a therapeutic target for age-related testosterone deficiency: from network collapse to clinical intervention. [PDF]

Front Endocrinol (Lausanne)
Zhou L, Tian X, Wang X, Lan X, Wang M, Li J, Dong L, Yu X, Yang F.   +8 more
europepmc   +1 more source