Results 171 to 180 of about 49,849 (243)

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

Advanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Yang Yu, Xueyan Wang, Xuemei Li, Jike Hu, Weigao Pu, Yunpeng Wang, Na Wang, Dedai Lu, Zhijian Han, Hao Chen   +14 more
wiley   +1 more source

Homocysteine affects macrophage polarization by altering m6A methylation of scavenger receptors CD209 and CD163L1. [PDF]

Epigenetics
Liang Y, Wang Y, Tan J, Shu J, Xu Y, Wang M, Yang S, Ma L.   +7 more
europepmc   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins. [PDF]

Front Immunol
Araujo G, Valencia LM, Martin-Ozimek A, Soto Y, Proctor SD.   +4 more
europepmc   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Cannabis sativa extracts inhibit LDL oxidation and the formation of foam cells in vitro, acting as potential multi-step inhibitors of atherosclerosis development. [PDF]

PLoS One
Musetti B, Kun A, Menchaca D, Rodríguez-Haralambides A, Varela J, Thomson L, Bahnson EM.   +6 more
europepmc   +1 more source

Tunneling Nanotube‐Mediated Transcellular Autophagy Alleviates Cadmium Induced Hepatocyte Injury

Advanced Science, EarlyView.
ROS accumulation is an important upstream signal for activating transcellular autophagy. Incomplete autophagy and TNT formation are necessary conditions for activating transcellular autophagy, and the disruption of the autophagic fusion mechanism is a trigger for activating transcellular autophagy.
Tao Wang, Li Wang, Jian Sun, Yan Chen, Waseem Ali, Yonggang Ma, Ruilong Song, Xishuai Tong, Jiaqiao Zhu, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou   +13 more
wiley   +1 more source

Class B scavenger receptor resists WSSV replication by recognizing the viral lipid molecule and promoting phagocytosis. [PDF]

J Virol
Huang Y-H, Guo X-L, Shan M-K, Yang G-W, Yang H-T.   +4 more
europepmc   +1 more source

Bio‐Inspired Strategy for Radiation‐Based Thermal Management and Utilization

Advanced Science, EarlyView.
Biological organisms have evolved remarkable strategies to manage and exploit thermal radiation. This review explores bio‐inspired systems that mimic these adaptations—such as radiative cooling, thermal regulation, thermal insulation, water harvesting, infrared camouflage, and infrared detection—and highlights their application in thermal management ...
Hyung Rae Kim, Won Bae Han, Se‐Yeon Heo, Yun Su Go, Suk‐Won Hwang, Young Min Song   +5 more
wiley   +1 more source

Interaction between lipid metabolism and macrophage polarization in atherosclerosis. [PDF]

iScience
Wang X, Xie Z, Zhang J, Chen Y, Li Q, Yang Q, Chen X, Liu B, Xu S, Dong Y.   +9 more
europepmc   +1 more source