Results 191 to 200 of about 49,849 (243)

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Cholesterol in the CNS: functions, recycling and remyelination. [PDF]

J Neuroinflammation
Wuerch EC, Yong VW.
europepmc   +1 more source

Near‐Infrared Afterglow Imaging‐Guided Surgical Resection and Synergistic Photodynamic‐Chemo Therapy of Breast Cancer

Advanced Science, EarlyView.
A CDSP NPs theranostic platform assembled from CDs and paclitaxel prodrugs is developed. CDSP NPs have long‐lasting NIR afterglow, penetrate deep tissues, and offer a high signal‐to‐noise ratio, enabling NIR afterglow imaging‐guided precise breast cancer removal to prevent recurrence.
Zixuan Li, Ranran Zhao, Qing Pei, Zhigang Xie, Min Zheng   +4 more
wiley   +1 more source

Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage. [PDF]

Cell Mol Neurobiol
Xu Y, Li W, Zhang J, Gao W, Zhang T, Chen Q, Wang N, Zhou Y, Zhang F, Qin J.   +9 more
europepmc   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Gut microbiota depletion accelerates hematoma resolution and neurological recovery after intracerebral hemorrhage via p-coumaric acid-promoted Treg differentiation. [PDF]

Theranostics
Zheng Y, Li Y, He X, Zhu Y, Xu S, Feng Y, Kuang Y, Chen H, Fan L, Huang H, Hu L, Yu X, Wu J, Jin L, Hu J, Fu X, Zeng H, Cao S, Wang L.   +18 more
europepmc   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Evidence, Mechanisms, and Clinical Implications of Microplastics and Nanoplastics As Emerging Cardiovascular Risk Factors: A Narrative Review. [PDF]

Cureus
Moorthy S, Kesavan S, Bhaskaran S, Balasubramanian G, Ambala M, Gogineni KK, Palaparthi EC, Rapeti LSK, Vivekanandan V, Periasamy P.   +9 more
europepmc   +1 more source

Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma

Advanced Science, EarlyView.
A microneedle (MN) patch that integrates novel bimetallic plasmonic nanozyme (BPNzyme) and traditional Chinese medicine β‐elemene (β‐ELE) has been rationally designed for ferroptosis pathway‐dependent combined therapy of melanoma. Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity ...
Wei Duan, Keying Xu, Yue Gao, Sheng Huang, Xueqian Xia, Xiang Liu, Shuangxue Pan, Chunpeng Jiao, Weijian Cheng, Yong Guo, Jingwen Zhao, Jia‐Wei Shen   +11 more
wiley   +1 more source

Unraveling the role of macrophages in diabetes: Impaired phagocytic function and therapeutic prospects. [PDF]

Medicine (Baltimore)
Rong B, Jiang H, Zhu W, Yang G, Zhou X, Lyu Z, Li X, Zhang J.   +7 more
europepmc   +1 more source