Results 261 to 270 of about 98,327 (303)
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Endothelial scavenger receptors
Progress in Lipid Research, 2006In the past few decades, cDNAs for endothelial scavenger receptors that bind to negatively charged molecules, particularly acetylated low density lipoproteins (Ac-LDL), have been cloned by expression cloning using modified LDL as ligands. A prototypic members of endothelial scavenger receptor family, namely, scavenger receptor class B type I (SR-BI ...
Hideki, Adachi, Masafumi, Tsujimoto
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Scavenger receptors in innate immunity
Current Opinion in Immunology, 1996Scavenger receptors are cell-surface proteins expressed by mammalian monocytes and macrophages and by invertebrate hemocytes, among other cell types. They exhibit distinctive ligand-binding properties, recognizing a wide range of ligands that include microbial surface constituents and intact microbes.
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Scavenger receptors in homeostasis and immunity
Nature Reviews Immunology, 2013Scavenger receptors were originally identified by their ability to recognize and to remove modified lipoproteins; however, it is now appreciated that they carry out a striking range of functions, including pathogen clearance, lipid transport, the transport of cargo within the cell and even functioning as taste receptors. The large repertoire of ligands
Johnathan, Canton +2 more
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Collagenous macrophage scavenger receptors
Current Opinion in Lipidology, 1996Collagen, the most abundant protein in the human body, is a major constituent of extracellular matrix. Among macrophage membrane proteins, type I and II scavenger receptors and MARCO contain a collagenous domain. Analysis of type I and II receptor knockout mice and histochemical studies indicate that these proteins play roles in scavenger, adhesion and
T, Kodama +5 more
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Hemoglobin and Heme Scavenger Receptors
Antioxidants & Redox Signaling, 2010Heme, the functional group of hemoglobin, myoglobin, and other hemoproteins, is a highly toxic substance when it appears in the extracellular milieu. To circumvent potential harmful effects of heme from hemoproteins released during physiological or pathological cell damage (such as hemolysis and rhabdomyolysis), specific high capacity scavenging ...
Nielsen MJ, Møller HJ, Moestrup SK.
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Macrophage scavenger receptors
Current Opinion in Lipidology, 1994Macrophage scavenger receptors are integral membrane proteins whose ability to bind and degrade modified LDL has implicated them in the process of atherosclerotic foam cell formation. Their ability to bind non-lipoprotein ligands suggests that they participate in other macrophage-associated host defense activities.
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Scavenger receptor regulation and atherosclerosis
BioFactors, 2000AbstractAtherosclerosis and its complications, such as coronary heart disease, heart infarction and stroke, are the leading causes of death in the developed world. High blood pressure, diabetes, smoking and a diet high in cholesterol and lipids clearly increase the likelihood of premature atherosclerosis, albeit other factors, such as the individual ...
ZINGG JM, RICCIARELLI, ROBERTA, AZZI A.
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Macrophage scavenger receptors and atherosclerosis
Trends in Cardiovascular Medicine, 1992The fatty streak is the earliest visible atherosclerotic lesion. Microscopically, this lesion consists of a subendothelial collection of macrophage foam cells that are characterized by their content of numerous lipid droplets. Investigations into the mechanisms responsible for foam cell formation have led to the identification of macrophage scavenger ...
H, Wu, K S, Moulton, C K, Glass
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Scavenger-Receptor Targeted Photodynamic Therapy¶
Photochemistry and Photobiology, 2000Covalent conjugation of a photosensitizer to a ligand that specifically recognized and internalized by a cell-surface receptor may be a way of improving the selectivity of photodynamic therapy (PDT). The class A Type-I scavenger receptor of macrophages, which among other ligands recognizes maleylated serum albumin and has a high capacity is a good ...
M R, Hamblin, J L, Miller, B, Ortel
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Identification of the haemoglobin scavenger receptor
Nature, 2001Intravascular haemolysis is a physiological phenomenon as well as a severe pathological complication when accelerated in various autoimmune, infectious (such as malaria) and inherited (such as sickle cell disease) disorders. Haemoglobin released into plasma is captured by the acute phase protein haptoglobin, which is depleted from plasma during ...
Madsen, Mette +6 more
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