Results 21 to 30 of about 709,109 (292)

Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. [PDF]

PLoS ONE, 2009
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the
Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, Arnauld Belmer, Katia Boutourlinsky, Denis Hervé, Jean-Marie Launay, Luc Maroteaux   +9 more
doaj   +1 more source

Classification of Serotonin Receptors

Journal of Cardiovascular Pharmacology, 1987
The subdivision of serotonin (5-HT) receptors into three classes, designated 5-HT1, 5-HT2, and 5-HT3, has been based on radioligand binding studies and experiments in isolated tissues. As a result of radioligand binding studies, two types of 5-HT recognition sites have been postulated. One site specifically labeled by [3H]5-HT was termed 5-HT1, and the
M, Göthert, E, Schlicker
openaire   +3 more sources

Serotonin receptor mechanisms in anti-depressant action [PDF]

, 2003
Bibliography: leaves 221-270.Serotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter.
Quested, Digby John
core   +1 more source

Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression

Frontiers in Behavioral Neuroscience, 2014
Decreased serotonergic activity has been implicated in anxiety and major depression, and antidepressants directly or indirectly increase the long-term activity of the serotonin system.
Paul R Albert, Faranak eVahid-Ansari, Faranak eVahid-Ansari, Christine eLuckhart, Christine eLuckhart   +4 more
doaj   +1 more source

A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.

PLoS ONE, 2013
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa.
Andrew M Dacks, Vincenzina Reale, Yeli Pi, Wujie Zhang, Joel B Dacks, Alan J Nighorn, Peter D Evans   +6 more
doaj   +1 more source

Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children

Health Technology Assessment, 2023
Background Antidepressants are commonly prescribed during pregnancy, despite a lack of evidence from randomised trials on the benefits or risks.
Heuvelman Hein, Davies Neil M, Ben-Shlomo Yoav, Emond Alan, Evans Jonathan, Gunnell David, Liebling Rachel, Morris Richard, Payne Rupert, Storey Claire, Viner Maria, Rai Dheeraj   +11 more
doaj   +1 more source

Glycogen Synthase Kinase-3 is an intermediate modulator of serotonin neurotransmission

Frontiers in Molecular Neuroscience, 2011
Serotonin is a neurotransmitter with broad functions in brain development, neuronal activity, and behaviors; and serotonin is the prominent drug target in several major neuropsychiatric diseases.
Xiaohua eLi, Abigail ePolter
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Behavioural Neurology, 2021
There are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and ...
Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-pan Li, Xi-xin Li, Zhu-Li Liu, Chao Ren   +7 more
doaj   +1 more source

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]

, 2009
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes, Caroline Nothdurfter, Tanasic, S., Rammes, G., Rupprecht, R., Eisensamer, Brigitte, Zieglgänsberger Walter, Christine Hosp, Tanasic, Sascha, Hosp Christine, Walter Zieglgänsberger, Rupprecht Rainer, Rammes, Gerhard, Sascha Tanasic, Hosp, C., Rammes Gerhard, Nothdurfter, C., Tanasic Sascha, Rupprecht, Rainer, Nothdurfter Caroline, Brigitte Eisensamer, Eisensamer, B., Zieglgänsberger, Walter, Zieglgänsberger, W., Hosp, Christine, Rainer Rupprecht, Nothdurfter, Caroline, Eisensamer Brigitte   +27 more
core   +2 more sources