Results 41 to 50 of about 2,570,395 (251)

Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Behavioural Neurology, 2021
There are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and ...
Hui-Hua Li, Xiao-Yan Yao, Sheng Tao, Xue Sun, Pan-pan Li, Xi-xin Li, Zhu-Li Liu, Chao Ren   +7 more
doaj   +1 more source

Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children

Health Technology Assessment, 2023
Background Antidepressants are commonly prescribed during pregnancy, despite a lack of evidence from randomised trials on the benefits or risks.
Heuvelman Hein, Davies Neil M, Ben-Shlomo Yoav, Emond Alan, Evans Jonathan, Gunnell David, Liebling Rachel, Morris Richard, Payne Rupert, Storey Claire, Viner Maria, Rai Dheeraj   +11 more
doaj   +1 more source

The role of serotonin 5-HT2A receptors in memory and cognition

Frontiers in Pharmacology, 2015
Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous system, especially in brain region essential for learning and cognition.
Gongliang Zhang, R. Stackman
semanticscholar   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Levo-Tetrahydroberberrubine Produces Anxiolytic-Like Effects in Mice through the 5-HT1A Receptor. [PDF]

PLoS ONE, 2017
Tetrahydroprotoberberines (THPBs) are isoquinoline alkaloids isolated from the Chinese herb Corydalis yanhusuo. In the present study, we performed competitive binding assays to examine the binding of l-THBr to neurotransmitter receptors known to be ...
Guiyun Mi, Shuai Liu, Jian Zhang, Huichun Liang, Yunyun Gao, Nuomin Li, Boyang Yu, Hongju Yang, Zheng Yang   +8 more
doaj   +1 more source

Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used

BMC Complementary and Alternative Medicine, 2019
Background Salvia officinalis has been used successfully for the treatment of hot flushes and excessive sweating during menopause. However, modes of actions have not been elucidated conclusively.
Carsten Tober, Roland Schoop
doaj   +1 more source

Effects of Electron Radiation on Serotonin Signaling and Reactivity of Rat Gastric Smooth Muscle

Toxics, 2023
Ionizing radiation in radiotherapy can disrupt cellular functions based on radiation type, energy, and dose. However, investigations on the effects of accelerated electrons, particularly on serotonin mediation, are limited.
Raina Ardasheva, Natalia Prissadova, Valentin Turiyski, Anna Tolekova, Athanas Krastev, Mina Pencheva, Veselin Popov   +6 more
doaj   +1 more source

A receptor-based analysis of local ecosystems in the human brain. [PDF]

, 2017
BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core   +1 more source

Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling

Frontiers in Cell and Developmental Biology, 2023
Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and muscarinic receptors. There is clinical evidence that
D. Kavindi Weerasinghe, Jason M. Hodge, Jason M. Hodge, Julie A. Pasco, Julie A. Pasco, Julie A. Pasco, Rasika M. Samarasinghe, Behnaz Azimi Manavi, Lana J. Williams, Lana J. Williams   +9 more
doaj   +1 more source

Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]

, 2011
Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT_2A receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg, A. G. Wade, A. McConnachie, Blier, Buntinx, C. B. Nemeroff, Celada, Demyttenaere, E. Buntinx, G. M. Crawford, Gillespie, Guy, L. Haazen, Landen, T. Schlaepfer   +14 more
core   +1 more source