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Tachykinins and tachykinin receptors in bone
Microscopy Research and Technique, 2002AbstractTachykinins are neuropeptides that are widely distributed in the body and function as neurotransmitters and neuromodulators. Five tachykinin subtypes: substance P (SP), neurokinin A, neurokinin B, neuropeptide K, and neuropeptide γ; and three receptor subtypes: neurokinin‐1, ‐2, and ‐3 receptors, have been identified.
Tetsuya, Goto, Teruo, Tanaka
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Tachykinins and tachykinin receptors: a growing family
Life Sciences, 2004The peptides of the tachykinin family are widely distributed within the mammalian peripheral and central nervous systems and play a well-recognized role as excitatory neurotransmitters. Currently, the concept that tachykinins act exclusively as neuropeptides is being challenged, since the best known members of the family, substance P, neurokinin A and ...
Jocelyn N, Pennefather +5 more
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Current Protocols in Pharmacology, 2010
AbstractDescribed in this unit are methods for obtaining, preparing, and testing smooth muscle preparations bearing tachykinin receptors to study the agonist or antagonist properties of test compounds. Concentration‐response curves to agonists are constructed to measure their ability to produce smooth muscle contractions and thus evaluate the potency ...
Stefania, Meini, Carlo Alberto, Maggi
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AbstractDescribed in this unit are methods for obtaining, preparing, and testing smooth muscle preparations bearing tachykinin receptors to study the agonist or antagonist properties of test compounds. Concentration‐response curves to agonists are constructed to measure their ability to produce smooth muscle contractions and thus evaluate the potency ...
Stefania, Meini, Carlo Alberto, Maggi
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Tachykinin receptors and the airways
Life Sciences, 1991The tachykinins, substance P, neurokinin A and neurokinin B, belong to a structural family of peptides. In mammalian airways, substance P and neurokinin A are colocalized to afferent C-fibres. Substance P-containing fibres are close to bronchial epithelium, smooth muscle, mucus glands and blood vessels.
N, Frossard, C, Advenier
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Tachykinins: receptor to effector
The International Journal of Biochemistry & Cell Biology, 1996Tachykinins belong to an evolutionarily conserved family of peptide neurotransmitters. The mammalian tachykinins include substance P, neurokinin A and neurokinin B, which exert their effects by binding to specific receptors. These tachykinin receptors are divided into three types, designated NK1, NK2 and NK3, respectively.
A M, Khawaja, D F, Rogers
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Tachykinin receptors in gastrointestinal motility
Regulatory Peptides, 1995For a long time research on the action of TKs on gastrointestinal tissue has been demonstrating the importance of the TKs as non-cholinergic stimulators of motility in most parts of the mammalian gastrointestinal tract. The past years witnessed the development of TK agonists and antagonists selective for the various receptor types, which prompted a ...
U Holzer-Petsche +1 more
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Tachykinins and tachykinin‐receptors in the rat pineal gland
European Journal of Neuroscience, 2005AbstractHigh‐pressure liquid chromatography of extracts of rat pineal glands, followed by radio immunological analysis with antibodies against tachykinins, demonstrated the presence of substance P, neurokinin A and neurokinin B in the superficial rat pineal gland.
Mukda, S +5 more
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Tachykinins and tachykinin receptors: effects in the genitourinary tract
Life Sciences, 2005Tachykinins (TKs) are a family of peptides involved in the central and peripheral regulation of urogenital functions through the stimulation of TK NK1, NK2 and NK3 receptors. At the urinary system level, TKs locally stimulate smooth muscle tone, ureteric peristalsis and bladder contractions, initiate neurogenic inflammation and trigger local and spinal
Candenas, M. Luz +5 more
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Tachykinins and Tachykinin Receptors: Structure and Activity Relationships
Current Medicinal Chemistry, 2004In addition to the classical neurotransmitters, acetylcholine and noradrenaline, a wide number of peptides with neurotransmitter activity have been identified in the past few years. Among them, the tachykinins substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) appear to act as mediators of nonadrenergic, noncholinergic (NANC) excitatory ...
T A, Almeida +6 more
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The mammalian tachykinin receptors
General Pharmacology: The Vascular System, 1995The tachykinins (TKs) are a family of small peptides which share the common C-terminal sequence Phe-X-Gly-Leu-MetNH2. Three peptides of this family, substance P, neurokinin A and neurokinin B, have an established role as neurotransmitters in mammals. 2.
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