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Mammalian Tachykinin Receptors
Annual Review of Neuroscience, 1991tachykinin system represents a typical ex ample; it comprises a group of multiple pep tides and demonstrates a func tional diversity at the levels of both peptide production and peptide recep tion. This system consists of three distinct peptides: substance P, substance K (neurokinin A), and neuromedin K (neurokinin B), all of which share the common ...
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THE STUDY OF TACHYKININ RECEPTORS
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Three high affinity receptors (NK1, NK2 and NK3) recognizing the C‐terminal end of tachykinins have been described, with probable endogenous ligands substance P (SP‐), neurokinin A and neurokinin B, respectively.2. Other receptors recognizing the N‐terminal regions of SP exist in adrenal medulla and central nervous system (CNS) with a low ...
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Molecular aspects of the tachykinin receptors
Regulatory Peptides, 1993Norma P Gérard, Craig Gérard, Lu Bao
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Tachykinin Receptor Antagonists and Cough
Pulmonary Pharmacology, 1996Several potent and selective antagonists for tachykinin receptors are now available and appear as powerful tools to investigate the physiological and pathological roles of tachykinins and to identify the type of receptor involved in their effect. Indeed, a lot of studies have shown that tachykinin NK2 receptor antagonists (SR 48968, MEN 10627) are able
Xavier Emonds-Alt, C Advenier
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The immunomodulatory effects of tachykinins and their receptors
Journal of Cellular Biochemistry, 2020AbstractTachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non‐neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune‐related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers.
Sahar Khorasani +3 more
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Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human
Autonomic Neuroscience, 2006Tachykinins (TKs), substance P (SP), neurokinin A (NKA) and B (NKB) are important peptide modulators of intestinal motility in animal species studied so far, including humans. Modulation of motility by TKs can occur at various levels, since these peptides are expressed in cholinergic excitatory motor neurons projecting to both circular and longitudinal
Alessandro, Lecci +3 more
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2002
Abstract The mammalian tachykinins, also known as neurokinins, are a family of small peptides that share the common COOH-terminal sequence, Phe-X-Gly-Leu-Met-NH2, whereX isa Val or Phe residue, and NH2 represents amidation of the COOH-terminus which is important for biological activity (Maggio 1988; Maggi et al .
Andrew D Medhurst, Douglas W P Hay
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Abstract The mammalian tachykinins, also known as neurokinins, are a family of small peptides that share the common COOH-terminal sequence, Phe-X-Gly-Leu-Met-NH2, whereX isa Val or Phe residue, and NH2 represents amidation of the COOH-terminus which is important for biological activity (Maggio 1988; Maggi et al .
Andrew D Medhurst, Douglas W P Hay
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Tachykinin receptors and intestinal motility
Canadian Journal of Physiology and Pharmacology, 1997Substance P (SP) and neurokinin A (NKA) are synthesized by enteric cholinergic motorneurons that project to the longitudinal and circular muscle of the mammalian intestine. Thus, acetylcholine, SP, and NKA are the excitatory neuromuscular transmitters in the intestine.
C A, Maggi +13 more
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Endomorphins interact with tachykinin receptors
Peptides, 2005Soon after the discovery of endomorphins several studies indicated differences between pharmacological effects of endomorphins and other MOR selective ligands, as well as differences between the effects of endomorphin I and endomorphin II. We now propose that these differences are the result of an additional non-opioid property of endomorphins, namely,
Piotr, Kosson +3 more
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Tachykinin receptors and airway pathophysiology
European Respiratory Journal, 1993The mammalian tachykinins (TKs), substance P and neurokinin A, are present in sensory nerve fibres in the upper and lower airways of various mammalian species, including humans. TKs are released from these afferent nerves in an "efferent" mode at peripheral level, especially in response to irritant stimuli.
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