Results 231 to 240 of about 78,914 (316)

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Spatial and Functional Roles of Syndecans in Skin Wound Healing. [PDF]

Int J Mol Sci
Park E, Kim HG, Un Y, Oh ES.
europepmc   +1 more source

Colorectal Cancer Organoid Model Reveals the Mechanisms of Irinotecan Resistance at Single‐Cell Resolution

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Objective Irinotecan, a standard therapeutic agent for metastatic colorectal cancer (mCRC), often faces significant limitations due to drug resistance, with treatment failure observed in approximately 30%–50% of patients, leading to poor clinical outcomes.
Yi Pan, Lin Chen, Yuqing Hu, Jie Chang, Xifeng Xu, ShuoChen Xu, YiWen Li, Jinlin Du, JianPing Wang, Wenxia Xu   +9 more
wiley   +1 more source

From theory to platelets: unraveling the history and complexities of biased signaling. [PDF]

Blood Vessel Thromb Hemost
Kendrick NC, Huang GH, Harvey GJ, Nieman MT.   +3 more
europepmc   +1 more source

Extensive Intracerebral Hemorrhage Involving Basal Ganglia and Frontal Lobe With Intraventricular and Subarachnoid Extension in a Triplet Pregnancy Following In Vitro Fertilization: A Case Report and Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Triplet births, particularly those achieved by assisted reproductive technologies, entail markedly elevated maternal and fetal risks, including hypertensive diseases. Intracerebral hemorrhage is an uncommon but devastating complication during the postpartum period.
Raman Goit, Prakash Gupta, Linh Nguyen, Shachi Patel, Karan Kumar Rana, Suman Jaiswal, Prateeti Bekoju, Ranju Shrestha, Daniel Nguyen   +8 more
wiley   +1 more source

Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. [PDF]

Arterioscler Thromb Vasc Biol
Rajala R, Griffin CT.
europepmc   +1 more source

Dextran sulfate activates the contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
Cheronis, J. C., Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kohl, Jacek, Siebeck, Matthias, Spannagl, Michael, Spies, Bernd   +7 more
core  

Spontaneous Perirenal Hemorrhage Mimicking Renal Rupture in a Long‐Term Hemodialysis Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Spontaneous perirenal hemorrhage (SPH) and spontaneous renal rupture (SRR) are rare emergencies that can be radiologically indistinguishable when hematomas are large, especially in hemodialysis patients. We report a 53‐year‐old man on long‐term hemodialysis who developed acute left flank pain 19 h after low‐molecular‐weight heparin.
Zhen Wang, Bo Yang, Yi Zhang, Xiaoqiang Li, Bin Wang, Jinghan Chen   +5 more
wiley   +1 more source

Acquired Coagulation Factor XIII Deficiency With Spontaneous Splenic Rupture: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Coagulation factor XIII deficiency (FXIIID) is a rare hemorrhagic disease, mainly manifested as skin ecchymosis and hematoma. Because of its atypical clinical manifestations and normal results of routine coagulation test, platelet count and function, it has brought great challenges to the diagnosis.
Jun Lu, Xijun Zhu
wiley   +1 more source

<i>Xanthium strumarium</i> L. Exhibits Potent Antiplatelet and Antithrombotic Effects by Modulating MAPK and PI3K/AKT Signaling Pathways and Inhibiting Ferric Chloride-Induced Thrombosis. [PDF]

Biomedicines
Akram AW, Lee GH, Baek SM, Kang J, Koo Y, Oh Y, Seo MS, Saba E, Lee DH, Rhee MH.   +9 more
europepmc   +1 more source