Results 1 to 10 of about 62,155 (265)
SOSHI-seq: a high-throughput screening assay to test the functionality of putative response elements for nuclear hormone receptors [PDF]
Scientific ReportsWe present a cheap, rapid, and versatile assay called SOSHI-seq (Screening of Self-transcribed Hormone Inducible response elements coupled to sequencing).
Shijia Wu +4 more
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Main Factors Involved in Thyroid Hormone Action
Molecules, 2021 The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi +3 more
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The Isoforms of Estrogen Receptor Alpha and Beta in Thyroid Cancer
Frontiers in Oncology, 2022 The incidence of thyroid cancer was predominant in women, indicating that the sex hormone may have a role in thyroid cancer development. Generally, the sex hormone exerts its function by binding to the correspondent nuclear receptors. Therefore, aberrant
Zhongqin Gong +10 more
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Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
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Hormone Selectivity in Thyroid Hormone Receptors [PDF]
Molecular Endocrinology, 2001 Separate genes encode thyroid hormone receptor subtypes TRalpha (NR1A1) and TRbeta (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological response. Compounds that discriminate between these subtypes in vivo may be useful in treating important medical problems such as obesity ...
R L, Wagner +9 more
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Environment International, 2020 Background: The presence of chemical pollutants in the environment can affect human health. Epidemiological and in vivo experimental studies reveal reprotoxic effects (undescended testis) of phthalates (diethylhexyl phthalate (DEHP), dibutyl phthalate ...
Valentine Suteau +6 more
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Impaired hair growth and wound healing in mice lacking thyroid hormone receptors. [PDF]
PLoS ONE, 2014 Both clinical and experimental observations show that the skin is affected by the thyroidal status. In hypothyroid patients the epidermis is thin and alopecia is common, indicating that thyroidal status might influence not only skin proliferation but ...
Constanza Contreras-Jurado +5 more
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Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance
Endocrine Connections, 2022 Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann +11 more
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Thyroid hormone and thyroid hormone nuclear receptors: History and present state of art
Endocrine Regulations, 2021 The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) and its cognate nuclear receptors.
Brtko Julius
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Independent Skeletal Actions of Pituitary Hormones [PDF]
Endocrinology and Metabolism, 2022 Over the past years, pituitary hormones and their receptors have been shown to have non-traditional actions that allow them to bypass the hypothalamus-pituitary-effector glands axis.
Se-Min Kim +5 more
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