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Therapeutic applications of thyroid hormone analogues [PDF]
, 2020 Cellular thyroid hormone homeostasis requires adequate function of: (1) thyroid hormone transporter proteins at the plasma membrane, (2) deiodinating enzymes and (3) nuclear thyroid hormone receptors (TRs).
Visser, W.E. (Edward), Visser, W. E.
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Thyroid-like function in the urochordate Ciona intestinalis [PDF]
, 2011 In the studies reported in the manuscript I investigated the involvement of Iodine and thyroxine (Thyroid Hormone, T4) in Ciona intestinalis metamorphosis. To date, the mechanisms regulating the metamorphosis of ascidians remain largely unknown.
Staiano, Leopoldo
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Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated
Jae Hee Lee, Eun Young Kim
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Coordination of mitochondrial biogenesis by thyroid hormone [PDF]
, 2011 International audience► We developed a model for different time courses in thyroid hormone-mediated gene transcription. ► Early induced thyroid hormone target genes are direct targets via thyroid hormone receptors.
Alexander Iwen, K. +3 more
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Frontiers in Endocrinology, 2014 Cerebellum development is sensitive to thyroid hormone (TH) levels, as THs regulate neuronal migration, differentiation and myelination. Most effects of THs are mediated by the TH receptor (TR) isoforms TRb1, TRb2 and TRa1.
Larissa Costa Faustino +1 more
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Frontiers in Endocrinology, 2022 Thyroid hormones, T3 (triiodothyronine) and T4 (thyroxine), induce a variety of long-term effects on important physiological functions, ranging from development and growth to metabolism regulation, by interacting with specific nuclear or cytosolic ...
Sandra Incerpi +20 more
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A novel variant of THRβ and its 4-year clinical course in a Korean boy with resistance to thyroid hormone [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα- and THRβ-encoded thyroid hormone receptors (THRs).
Sejin Kim +4 more
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1A. Thyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
, 2019 Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [10]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and cardiovascular
Hollenberg, Anthony N. +2 more
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Ecotoxicology and Environmental Safety, 2023 Benzisothiazolinone (BIT), one of the most widely used antimicrobial agents in consumer products, has frequently been detected in the water environment. The present study was conducted to determine the adverse effects of BIT on the thyroid neuroendocrine
Sujin Lee +4 more
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Thyroid Hormone Receptor Mutations in Cancer and Resistance to Thyroid Hormone: Perspective and Prognosis [PDF]
, 2011 Thyroid hormone, operating through its receptors, plays crucial roles in the control of normal human physiology and development; deviations from the norm can give rise to disease. Clinical endocrinologists often must confront and correct the consequences
Martin L. Privalsky, Meghan D. Rosen
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