Results 41 to 50 of about 1,086,464 (298)

TRH: Pathophysiologic and clinical implications [PDF]

, 1985
Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
Pickardt, C. R., Scriba, Peter Christian
core   +1 more source

Bioactivity of Thyroid Hormone Analogs at Cancer Cells

Frontiers in Endocrinology, 2018
In the context of genomic thyroid hormone actions in normal (noncancer) cells that involve primary interactions with nuclear thyroid hormone receptors (TRs), L-thyroxine (T4), and 3,3′,5′-triiodo-L-thyronine (reverse T3, rT3) have little bioactivity.
Paul J. Davis, Paul J. Davis, Heng-Yuan Tang, Aleck Hercbergs, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Kelly A. Keating, Shaker A. Mousa   +9 more
doaj   +1 more source

Mechanism of thyroid-hormone regulated expression of the SERCA genes in skeletal muscle: Implications for thermogenesis [PDF]

, 2001
Thyroid hormone increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (SR) in skeletal muscle, thereby increasing the energy-turnover associated with Ca2+-cycling during contraction and rest. The fast-muscle isoform of the Ca2+-ATPase (SERCA1)
Hardeveld, C., Muller, A., Van der Linden, C. G., Simonides, W.S., Van Hardeveld, C., van der Linden, C.G., Thelen, M.H.M., Linden, C.G., van der, Simonides, W. S., Thelen, M. H.M.   +9 more
core   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Functional role of the CXCR4 chemokine receptor in thyroid cancer [PDF]

, 2009
Thyroid cancer is the most common endocrine malignancy and its incidence is increasing worldwide. We previously found that normal rat thyroid cells, transduced with papillary thyroid cancer (PTC)-related oncogenes, display an inflammatory signature, that
Avilla, Elvira
core   +1 more source

Thyroid Stimulating Hormone Receptor

Molecular Imaging and Radionuclide Therapy, 2017
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role
openaire   +2 more sources

Interaction of Human Chorionic Gonadotropin (hCG) and Asialo-hCG with Recombinant Human Thyrotropin Receptor. [PDF]

, 1994
hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma
Mann, K., Grossmann, M., Derwahl, M., Hoermann, R., Broecker, M.   +4 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Evolutionary Adaptation of the Thyroid Hormone Signaling Toolkit in Chordates

Cells, 2021
The specification of the endostyle in non-vertebrate chordates and of the thyroid gland in vertebrates are fundamental steps in the evolution of the thyroid hormone (TH) signaling to coordinate development and body physiology in response to a range of ...
Alfonso Esposito, Luca Ambrosino, Silvano Piazza, Salvatore D’Aniello, Maria Luisa Chiusano, Annamaria Locascio   +5 more
doaj   +1 more source

Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the Siberian hamster (Phodopus sungorus) [PDF]

, 2013
Peer ...
de Vries Emmely M., Bolborea Matei, Emmely M de Vries, de Vries, Emmely M, Ebling Francis J. P., Bolborea, Matei, Morgan, Peter J, Mercer, Julian G, Annika Herwig, Wilson Dana, Mercer, Julian G., Morgan, Peter J., Matei Bolborea, Francis J P Ebling, Herwig, Annika, Ebling, Francis J P, Barrett, Perry, Perry Barrett, Dana Wilson, Julian G Mercer, Mercer Julian G., Ebling, Francis J. P., Wilson, Dana, Herwig Annika, Barrett Perry, Vries, Emmely M. de, Morgan Peter J., Peter J Morgan   +27 more
core   +1 more source