Results 31 to 40 of about 1,185,623 (252)

Resistance to Thyroid Hormone in the Absence of Mutations in the Thyroid Hormone Receptor Genes

, 2004
Resistance to thyroid hormone (RTH) is a syndrome of reduced tissue sensitivity to thyroid hormone. In the majority of subjects, RTH is caused by mutant thyroid hormone receptors (TR) ß molecules that interfere with the function of the normal TRß, thus ...
Refetoff, Samuel, Reutrakul, Sirimon, Sadow, Peter M, Mannavola, Deborah, Pohlenz, Joachim, Weiss, Roy E, Dennis, Kimberly, Kimberly Dennis, Samuel Refetoff, Deborah Mannavola, Roy E. Weiss, Sirimon Reutrakul, Joachim Pohlenz, Peter M. Sadow   +13 more
core   +1 more source

Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy

Oftalʹmologiâ, 2014
Purpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune ...
V. G. Likhvantseva, O. A. Gontyurova, E. A. Rudenko, T. N. Saphonova, K. A. Kuzmin, N. Y. Sviridenko   +5 more
doaj   +3 more sources

Discovery & development of small molecule allosteric modulators of glycoprotein hormone receptors

Frontiers in Endocrinology, 2015
Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid stimulating hormone (TSH) are heterodimeric proteins with a common subunit and hormone-specific subunit.
Selvaraj G Nataraja, Henry N Yu, Stephen S Palmer   +2 more
doaj   +1 more source

Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors

Diseases, 2020
Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings.
Duaa Althumairy, Xiaoping Zhang, Nicholas Baez, George Barisas, Deborah A. Roess, George R. Bousfield, Debbie C. Crans   +6 more
doaj   +1 more source

Complexity of Genomic Actions Controlled by Thyroid Hormone Receptors [PDF]

, 2019
This thesis uses a multimodality approach to gain more insight into the complexity of the genomic actions of thyroid hormone ...
Wejaphikul, Karn, Wejaphikul, K. (Karn)
core   +1 more source

Thyroid Hormones Play Role in Sarcopenia and Myopathies

Frontiers in Physiology, 2018
Skeletal muscle maintains posture and enables movement by converting chemical energy into mechanical energy, further contributing to basal energy metabolism.
Flavia F. Bloise, Thamires S. Oliveira, Aline Cordeiro, Tania M. Ortiga-Carvalho   +3 more
doaj   +1 more source

Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis--A Cohort Study in a Group of Thyroid Carcinoma Patients. [PDF]

PLoS ONE, 2016
BACKGROUND/OBJECTIVES:Thyroid hormone receptors are present on brown adipose tissue (BAT), indicating a role for thyroid hormone in the regulation of BAT activation.
Evie P M Broeders, Guy H E J Vijgen, Bas Havekes, Nicole D Bouvy, Felix M Mottaghy, Marleen Kars, Nicolaas C Schaper, Patrick Schrauwen, Boudewijn Brans, Wouter D van Marken Lichtenbelt   +9 more
doaj   +1 more source

1A. Thyroid hormone receptors in GtoPdb v.2025.3 [PDF]

Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [13, 2]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and ...
Hollenberg, Anthony N., Webb, Paul, Forrest, Douglas   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Bioactivity of Thyroid Hormone Analogs at Cancer Cells

Frontiers in Endocrinology, 2018
In the context of genomic thyroid hormone actions in normal (noncancer) cells that involve primary interactions with nuclear thyroid hormone receptors (TRs), L-thyroxine (T4), and 3,3′,5′-triiodo-L-thyronine (reverse T3, rT3) have little bioactivity.
Paul J. Davis, Paul J. Davis, Heng-Yuan Tang, Aleck Hercbergs, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Kelly A. Keating, Shaker A. Mousa   +9 more
doaj   +1 more source