Results 51 to 60 of about 121,615 (309)

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis [PDF]

, 2017
Thyroid hormones (THs) are essential for embryonic brain development but the genetic mechanisms involved in the action of maternal THs (MTHs) are still largely unknown.
A Tallafuss, AC Lekven, AC Lekven, ALS Dowling, AP Halestrap, AV Gore, B Langmead, C Schuurmans, C Trapnell, CB Kimmel, CC Thompson, CM Armour, D Croft, D Lopez-Espindola, D Zada, DM Power, E Vrieze de, ECH Friesema, ECH Friesema, ECH Friesema, F Boukhtouche, F Chatonnet, F Chatonnet, F Supek, FJ Arjona, GD Vatine, GO Consortium, GR Williams, H Dong, H Gao, H Heuer, H Iwayama, J Bernal, J Chang, J Delbaere, J Jin, J Patel, J Schindelin, JJ Essner, JJ Essner, K Wallis, KR Holden, L Boccone, LA Desouza, MA Campinho, MA Campinho, MD Robinson, MF Batista, PC Holm, RB MacDonald, RS Dezonne, RT Zoeller, RT Zoeller, S Bertrand, S Horn, S Kersseboom, S Mayerl, S Skah, S-X Wu, T Pierfelice, VM Darras, VW Edward, Y Katsuyama, Y-C Cheng   +63 more
core   +2 more sources

Bioactivity of Thyroid Hormone Analogs at Cancer Cells

Frontiers in Endocrinology, 2018
In the context of genomic thyroid hormone actions in normal (noncancer) cells that involve primary interactions with nuclear thyroid hormone receptors (TRs), L-thyroxine (T4), and 3,3′,5′-triiodo-L-thyronine (reverse T3, rT3) have little bioactivity.
Paul J. Davis, Paul J. Davis, Heng-Yuan Tang, Aleck Hercbergs, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Kelly A. Keating, Shaker A. Mousa   +9 more
doaj   +1 more source

Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective [PDF]

Endocrine-Related Cancer, 2013
Thyroid hormones (THs) may play a role in diseases other than hyper- and hypothyroidism. Several lines of evidence suggest tumor-promoting effects of TH and TH receptors. They are possibly mediated by phosphatidylinositol-3-kinase and MAPK and involve among others stimulation of angiogenesis via αvβ3.
Möller, Lars, Führer, Dagmar
openaire   +3 more sources

Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]

PLoS ONE, 2011
BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen, Wei Wu, Guizhen Du, Renping Liu, Lugang Yu, Hong Sun, Xiumei Han, Yi Jiang, Wei Shi, Wei Hu, Ling Song, Yankai Xia, Shoulin Wang, Xinru Wang   +13 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells

Stem Cell Research, 2019
Oligodendrocyte precursor cells (OPCs) differentiation from multipotent neural stem cells (NSCs) into mature oligodendrocytes is driven by thyroid hormone and mediated by thyroid hormone receptors (TRs).
Vito Antonio Baldassarro, Wojciech Krężel, Mercedes Fernández, Brigitte Schuhbaur, Luciana Giardino, Laura Calzà   +5 more
doaj   +1 more source

Hypothyroidism and nephrotic syndrome: why, when and how to treat [PDF]

, 2017
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS).
Barbano, Biagio, Cianci, Rosario, Di Mario, Francesca, Gigante, Antonietta, Isidori, Andrea, Pofi, Riccardo, Rivoli, Laura, Rosato, Edoardo   +7 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Ability of the Right Ventricle to Serve as a Systemic Ventricle in Response to the Volume Overload at the Neonatal Stage

Biology, 2022
Background: In children with hypoplastic left heart syndrome (HLHS), volume overload (VO) is inevitable, and the right ventricle (RV) pumps blood into the systemic circulation.
Chunxia Zhou, Debao Li, Qing Cui, Qi Sun, Yuqing Hu, Yingying Xiao, Chuan Jiang, Lisheng Qiu, Haibo Zhang, Lincai Ye, Yanjun Sun   +10 more
doaj   +1 more source