Results 71 to 80 of about 1,185,623 (252)

Distinct PXR Inverse Agonism Mechanisms Rely on Differential Ligand‐induced Co‐Regulator Recruitment

Angewandte Chemie, EarlyView.
Pregnane X receptor (PXR) antagonism is ligand‐encoded: SPA70 recruits corepressors NCoR1 (nuclear receptor corepressor 1)/SMRT (silencing mediator for retinoid and thyroid‐hormone receptors) while binding coactivators, and is modulated by retinoid X receptor alpha (RXRα); MI891 causes cytoplasmic retention and corepressor‐dependent repression ...
Rajamanikkam Kamaraj, Azam Rashidian, Dharani Sai Sreekanth Nellore, Levi Miederer, Ivana Mejdr, Radim Nencka, Thales Kronenberger, Petr Pavek   +7 more
wiley   +2 more sources

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

The thyroid hormone receptors: molecular basis of thyroid hormone resistance.

, 1992
Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identification of the T3 receptor as the product of the proto-oncogene c-erbA. Recognition of subsets of receptors with and without T3-binding properties and of
De Nayer, Philippe
core   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Thyroid hormone receptors bind to defined regions of the growth hormone and placental lactogen genes

, 1986
peer reviewedThe intracellular receptor for thyroid hormone is a protein found in chromatin. Since thyroid hormone stimulates transcription of the growth hormone gene through an unknown mechanism, the hypothesis that the thyroid hormone-receptor complex ...
Rousseau, Guy, Economidis, I V, Economidis, Ioannis V, Rousseau, Guy G, Voz, M L, Belayew, Alexandra, Voz, Marianne, Barlow, J W, Martial, Joseph, Mathy-Harter, M, Martial, J A, Barlow, John W, Eliard, Pierre H, Mathy, Marianne, Eliard, P H, Belayew, A., De Nayer, Philippe   +16 more
core   +3 more sources

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Thyroid gland dysfunction and its effect on the cardiovascular system: a comprehensive review of the literature

Endokrynologia Polska, 2020
There is an intimate and functional relationship between the cardiovascular system and the thyroid gland; from sharing the same embryologic origin to modulating each of the components of the heart for a normal function. Due to this relationship, patients
Navid Ahmadi, Faisal Ahmadi, Masehullah Sadiqi, Katarzyna Ziemnicka, Andrzej Minczykowski   +4 more
doaj   +1 more source

Thyroid state-dependent effect of retinoic acid on thyroid hormone and retinoic acid receptors

, 1994
Thyroid state-dependent effect of retinoic acid on thyroid hormone and retinoic acid ...
MACCHIA, ENRICO, Canale, D.
core  

Involvement of the hypothalamic-pituitary-thyroid axis and its interaction with the hypothalamic-pituitary-adrenal axis in the ontogeny of avian thermoregulation: a review [PDF]

, 2008
The emergence of thermoregulation in avian species is a complex matter in which neural as well as hormonal processes are involved. In a previous paper, the neural aspects of primary avian thermoregulation were discussed.
Brand, H., van den, Kemp, B., Bruggeman, V., Debonne, M., Decuypere, E., Baarendse, P.J.J., E. DECUYPERE, V. BRUGGEMAN, M. DEBONNE, P.J.J. BAARENDSE, H. VAN DEN BRAND, B. KEMP   +11 more
core   +1 more source