Results 81 to 90 of about 1,185,623 (252)

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue

Frontiers in Cellular Neuroscience, 2019
Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion.
Elisa Landucci, Annunziatina Laurino, Lorenzo Cinci, Manuela Gencarelli, Laura Raimondi   +4 more
doaj   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Expression of Thyroid Hormone Receptors in Intracranial Meningiomas

Kaohsiung Journal of Medical Sciences, 2003
Thyroid hormone has a unique function in human organs. Many of its effects occur at the level of gene expression and are mediated by thyroid hormone receptors (TRs). We investigated the relationship between TRs and the prognosis of meningiomas.
Chih-Jen Wang, Pi-Chu Lin, Shen-Long Howng   +2 more
doaj   +1 more source

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

, 1995
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-
Bernd Gloss, Söderström, Mats,, Yasutomi Kamei, Kurokawa, R.,, Andreas J. Hörlein, Gloss, B.,, Rosenfeld, M. G.,, Torchia, J.,, Anders M. Näär, Thorsten Heinzel, Joseph Torchia, Ryan, A.,, Riki Kurokawa, Christopher K. Glass, Hörlein, A. J.,, Michael G. Rosenfeld, Glass, C. K.,, Kamei, Y.,, Heinzel, T.,, Mats Söderström, Aimee Ryan, Näär, A. M.,   +21 more
core   +1 more source

Receptors of thyroid hormones [PDF]

, 2014
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta.
Aranda, Ana, Zambrano, Alberto, Alonso-Merino, Elvira   +2 more
core   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Psychological well-being on thyroid hormone replacement [PDF]

Despite 100 years after the discovery of thyroxine, controversy still exists regarding optimal thyroid hormone replacement therapy. Several anecdotal reports suggest that thyroxine alone therapy does not normalise psychological wellbeing.
Saravanan, Ponnusamy
core  

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

Reduced expression of thyroid hormone receptors and beta-adrenergic receptors in human failing cardiomyocytes. [PDF]

, 2008
An altered thyroid hormone profile has been reported in patients with congestive heart failure. However, information regarding the status of thyroid hormone receptors in human failing cardiomyocytes is lacking. Therefore the expression of thyroid hormone
P. A. Modesti, A. Modesti, LUCCHESE, Gianluca, Modesti, Alessandra, M. Maccherini, Modesti, Pietro Amedeo, Gamberi, Tania, M. Chiavarelli, M. Marchetta, T. Gamberi, Marchetta, Matilde   +10 more
core   +2 more sources