Results 91 to 100 of about 1,185,623 (252)

Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor

Frontiers in Endocrinology, 2018
The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This structurally complex receptor is a member of the G-protein coupled receptor (GPCR) superfamily of membrane receptors.
Alfredo Ulloa-Aguirre, Teresa Zariñán, Eduardo Jardón-Valadez, Rubén Gutiérrez-Sagal, James A. Dias   +4 more
doaj   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Frequency of Dyslipidemia in Patients Having Subclinical Hypothyroidism

Journal of Gandhara Medical and Dental Sciences, 2016
INTRODUCTION Thyroid hormone by binding to the thyroid hormone receptors affects metabolism and growth in nearly all tissues of the body. Thyroid hormones play vital role in the synthesis and metabolism of lipids. The reduced secretion of thyroxine (T4)
Shah Zeb, Shafaq Naz, Najeeb Ullah
doaj   +1 more source

A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity [PDF]

, 2008
Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of
Hiroyuki NAMBA, Namba, Hiroyuki, Saenko, Vladimir, Yamashita, Shunichi, Akulevich, Natallia, Yuka NAKAZAWA, Vladimir SAENKO, Sedliarou, Ilya, Michiko MATSUSE, Rogounovitch, Tatiana, Mitsytake, Norisato, Natallia AKULEVICH, Shunichi YAMASHITA, Tatiana ROGOUNOVITCH, Nakazawa, Yuka, Matsuse, Michiko, Norisato MITSUTAKE, Ilya SEDLIAROU   +17 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

Arthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic, Pascal Claudepierre, Tat Thang Vo, Tran Trong Khoi Le, Siham Iggui, Laetitia Penso, Emilie Sbidian, Laura Pina Vegas   +7 more
wiley   +1 more source

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

, 2017
Significance This study changes our understanding of how thyroid hormone acts. Thyroid hormone receptors are considered typical nuclear receptors that bind to DNA and, after binding, alter the expression of their target genes and regulate ...
David L. Armstrong, Petra Kleinbongard, Karl-Heinz Strucksberg, Pollard, Andrea S., Eddy Rijntjes, Præstholm, Stine M., Grøntved, Lars; id_orcid, Kathrin Engels, J. H. Duncan Bassett, Zwanziger, Denise, Gassen, Janina, Lars Grøntved, Rozman, Jan, Engels, Kathrin, Denise Zwanziger, Logan, John, Williams, Graham R., Jan Rozman, Rijntjes, Eddy, Bassett, J. H.Duncan, Janina Gassen, Hönes, G. Sebastian, Liao, Xiao Hui, Rakov, Helena, Martin Hrabe de Angelis, Latteyer, Sören, Armstrong, David L., Sören Latteyer, Helmut Fuchs, Stine M. Præstholm, Eugenie Werbenko, Josef Köhrle, Werbenko, Eugenie, Refetoff, Samuel, John Logan, G. Sebastian Hönes, Xiao-Hui Liao, Köhrle, Josef, Klein-Hitpass, Ludger, Andrea S. Pollard, Kleinbongard, Petra, Graham R. Williams, Samuel Refetoff, De Angelis, Martin Hrabe, Ludger Klein-Hitpass, Strucksberg, Karl Heinz, Fuchs, Helmut, Führer, Dagmar, Helena Rakov, Valerie Gailus-Durner, Lars C. Moeller, Dagmar Führer, Majken S. Siersbæk, Gailus-Durner, Valerie, Siersbæk, Majken S., Moeller, Lars C.   +55 more
core   +1 more source

Genetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis

Arthritis &Rheumatology, EarlyView.
Objective Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5% to 15% of the general population and has recently been identified as an osteoarthritis risk factor. However, its biologic pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H. G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce B. J. van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Design of azine antioxidants for sustainable biodiesel: integrating structural characterization and molecular modeling

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The growing global demand for sustainable energy solutions has intensified the search for renewable alternatives to fossil fuels, with biodiesel emerging as a promising candidate due to its biodegradability and lower emissions. However, its large‐scale application is limited by low oxidative stability, which compromises storage and performance.
Patricia R. S. Wenceslau, Chris H. J. Franco, Leonardo R. de Almeida, Vitor S. Duarte, Ronaldo G. F. Junior, Guilherme Paixão, Antônio S. N. Aguiar, Gilberto L. B. de Aquino, Leonardo G. Costa, Leonardo L. Borges, Hamilton B. Napolitano   +10 more
wiley   +1 more source

RESISTANCE TO THYROID HORMONE DUE TO A NOVEL THR- MUTATION IN A PATIENT WITH THYROID AGENESIS

, 2018
Refetoff Syndrome is a rare disorder characterized by resistance to thyroid hormone (RTH). The coexistence of RTH and thyroid dysgenesis is a rare event. Up to now, only four cases of ectopic gland and RTH have been reported.
Maria Scavone
core   +1 more source