Results 91 to 100 of about 63,636 (263)
PLoS ONE, 2016 Di-(2-ethylhexyl) phthalate (DEHP) has the potential to disrupt the thyroid endocrine system, but the underlying mechanism is unknown. In this study, zebrafish (Danio rerio) embryos were exposed to different concentrations of DEHP (0, 40, 100, 200, 400 ...
Pan-Pan Jia +7 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley +1 more source
Scientific ReportsWe present a cheap, rapid, and versatile assay called SOSHI-seq (Screening of Self-transcribed Hormone Inducible response elements coupled to sequencing).
Shijia Wu +4 more
doaj +1 more source
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Annals of Neurology, EarlyView.Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang +45 more
wiley +1 more source
Thyroid hormone receptor and thyroid hormone refractory disease.
Nihon Naika Gakkai Zasshi, 1999 転写制御の分子メカニズムに関する研究が,ここ数年顕著に進展している.転写制御に重要な働きを持つ転写共役因子がいくつか同定され,転写促進および抑制機構,転写制御とクロマチンの構造変化の関連などが解明され始めた.転写調節因子としての核内受容体を見たとき,甲状線ホルモン受容体(TR)はレチノイン酸受容体とともにもっとも典型的な転写因子型受容体であり,その作用機構は多くのbig labによって精力的に研究されている.一方,甲状腺ホルモン不応症から見出されるTR異常は, TRの機能と構造に重要な情報を提供してきた.疾患モデルとして,トランスジェニックマウスやノックアウトマウスの作成と解析も行われている.
openaire +2 more sources
The Anatomical Record, EarlyView.Abstract Scientists have been captivated by the ability to regenerate, focusing on uncovering the mechanisms of epimorphic regeneration and applying them to human medicine. The axolotl (Ambystoma mexicanum) has become the most intensively studied model in tetrapod regeneration research, particularly concerning limb regeneration.
Vivien Bothe, Nadia Fröbisch
wiley +1 more source
Beyond Hormone Levels: Thyroid Hormone Signaling from Neurogenesis to Alzheimer’s Disease
CellsThyroid hormones (THs) critically regulate metabolism and the central nervous system (CNS) functions, acting as key factors in neuronal differentiation, synaptogenesis and myelination.
Cristina Del Seppia, Laura Sabatino
doaj +1 more source
The Anatomical Record, EarlyView.This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose +2 more
wiley +1 more source
Essential embryology for the Canadian pathologists’ assistant
Anatomical Sciences Education, EarlyView.Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci +4 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source