Results 111 to 120 of about 1,086,464 (298)

SOSHI-seq: a high-throughput screening assay to test the functionality of putative response elements for nuclear hormone receptors

open access: yesScientific Reports
We present a cheap, rapid, and versatile assay called SOSHI-seq (Screening of Self-transcribed Hormone Inducible response elements coupled to sequencing).
Shijia Wu   +4 more
doaj   +1 more source

Thyroid Hormone Resistance Syndromes

open access: yes, 2019
Syndromes with impaired sensitivity to thyroid hormone (TH) include three types of resistance to thyroid hormone (RTH) syndromes (RTHβ, RTHα, and nonTR-RTH) and also include patients with defects in TH transport into cells (thyroid hormone cell membrane ...
Refetoff, Samuel   +3 more
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

open access: yesThe Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose   +2 more
wiley   +1 more source

Characterization of a Low Affinity Thyroid Hormone Receptor Binding Site within the Rat GLUT4 Gene Promoter

open access: yes, 2023
Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle.
Dohm, G. Lynis   +4 more
core  

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

open access: yesArthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic   +7 more
wiley   +1 more source

Beyond Hormone Levels: Thyroid Hormone Signaling from Neurogenesis to Alzheimer’s Disease

open access: yesCells
Thyroid hormones (THs) critically regulate metabolism and the central nervous system (CNS) functions, acting as key factors in neuronal differentiation, synaptogenesis and myelination.
Cristina Del Seppia, Laura Sabatino
doaj   +1 more source

Thyroid hormone receptor and thyroid hormone refractory disease.

open access: yesNihon Naika Gakkai Zasshi, 1999
転写制御の分子メカニズムに関する研究が,ここ数年顕著に進展している.転写制御に重要な働きを持つ転写共役因子がいくつか同定され,転写促進および抑制機構,転写制御とクロマチンの構造変化の関連などが解明され始めた.転写調節因子としての核内受容体を見たとき,甲状線ホルモン受容体(TR)はレチノイン酸受容体とともにもっとも典型的な転写因子型受容体であり,その作用機構は多くのbig labによって精力的に研究されている.一方,甲状腺ホルモン不応症から見出されるTR異常は, TRの機能と構造に重要な情報を提供してきた.疾患モデルとして,トランスジェニックマウスやノックアウトマウスの作成と解析も行われている.
openaire   +2 more sources

1A. Thyroid hormone receptors in GtoPdb v.2025.3 [PDF]

open access: yes
Thyroid hormone receptors (TRs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [13, 2]) are nuclear hormone receptors of the NR1A family, with diverse roles regulating macronutrient metabolism, cognition and ...
Hollenberg, Anthony N.   +2 more
core   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu   +15 more
wiley   +1 more source

Hormônio da tireóide (T3) e sua influência sobre a matriz extracelular: efeitos na interação astrócito-neurônio [PDF]

open access: yes, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Neurociências.O hormônio da tireóide, T3, é essencial para o desenvolvimento e diferenciação em muitos órgãos, inclusive no SNC ...
Aguiar, Cláudia Beatriz Nedel Mendes de
core  

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