Results 61 to 70 of about 1,086,464 (298)

Efeito do T3 reverso sobre o estresse oxidativo induzido pelo hipotireoidismo congênito em hipocampo de ratos imaturos: envolvimento de mecanismos não genômicos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.Abstract : Congenital hypothyroidism can lead to a variety of neurochemical and morphophysiological ...
Domingues, Juliana Tonietto
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Van Wyk-Grumbach syndrome a great masquerader of primary hypothyroidism

Journal of Clinical and Scientific Research
Children with primary hypothyroidism typically present with delayed growth and development, precocious puberty but on rare occasions can present with pituitary macroadenoma. This is called Van Wyk-Grumbach syndrome (VWGS).
Beatrice Anne, Vivek Kumar, Mounica Tavva   +2 more
doaj   +1 more source

Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses

BMC Genomics, 2011
Background Disruption of thyroid hormone signalling can alter growth, development and energy metabolism. Thyroid hormones exert their effects through interactions with thyroid receptors that directly bind thyroid response elements and can alter ...
Paquette Martin A, Dong Hongyan, Gagné Rémi, Williams Andrew, Malowany Morie, Wade Mike G, Yauk Carole L   +6 more
doaj   +1 more source

Receptors of thyroid hormones.

Pediatric endocrinology reviews : PER, 2013
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta. These receptors act as hormone-dependent transcription factors by binding to DNA motifs located in the regulatory regions of target genes and recruiting coregulators (coactivators and ...
Aranda, Ana, Alonso-Merino, Elvira, Zambrano, Alberto   +2 more
openaire   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae

Ecotoxicology and Environmental Safety
Homosalate (HS) and octisalate (OS), which are used in sunscreen for the purpose of blocking ultraviolet rays, are frequently detected in water environment.
Yujin Ka, Inhye Lee, Kyunghee Ji
doaj   +1 more source

Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin [PDF]

, 2013
There remains a critical need for new therapeutics that promote wound healing in patients suffering from chronic skin wounds. This is, in part, due to a shortage of simple, physiologically and clinically relevant test systems for investigating candidate ...
Paredes Roberto, Matthias Augustin, Jennifer E Kloepper, Amaya, Enrique; id_orcid, Roberto Paredes (452874), Pattwell David M., Natalia T. Meier (452870), Enrique Amaya, Matthias Augustin (452876), Haslam Iain S., Augustin Matthias, Paus Ralf, Hardman, Matthew J, Kloepper, Jennifer E, Paus, Ralf, Sebastian Debus, Pattwell, David M., Wolfgang Funk, Matthew J Hardman, Wolfgang Funk (405807), Kloepper Jennifer E., Meier Natalia T., Matthew J. Hardman (452878), Amaya, Enrique, Zhang, Guo You, Amaya Enrique, Debus, Sebastian, Zhang Guo-You, Vladimir Emelianov (452873), Jennifer E. Kloepper (452877), Paredes, Roberto, Emelianov Vladimir, Guo-You Zhang, Sebastian Debus (452875), Hardman Matthew J., Haslam, Iain S., Funk Wolfgang, Hardman, Matthew J., Augustin, Matthias, Pattwell, David M, Kloepper, Jennifer E., Haslam, Iain S, Enrique Amaya (31703), Ralf Paus (261703), Emelianov, Vladimir, Haslam, Iain, Zhang, Guo-You, Natalia T Meier, Debus Sebastian, Meier, Natalia T., Vladimir Emelianov, Iain S Haslam, Roberto Paredes, David M. Pattwell (452872), Ralf Paus, Meier, Natalia T, Guo-You Zhang (397743), Funk, Wolfgang, Iain S. Haslam (452871), David M Pattwell   +59 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source