Results 21 to 30 of about 62,155 (265)
A novel variant of THRβ and its 4-year clinical course in a Korean boy with resistance to thyroid hormone [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2023 Thyroid hormone resistance (RTH) is characterized by a decreased sensitivity of target tissues to thyroid hormones due to a defect in the THRα- and THRβ-encoded thyroid hormone receptors (THRs).
Sejin Kim +4 more
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Thyroid hormone receptors and cancer [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013 Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the actions of the thyroid hormone (T3) in development, growth, and differentiation. The THRA and THRB genes encode several TR isoforms that express in a tissue- and development-dependent manner.
Won Gu, Kim, Sheue-yann, Cheng
openaire +2 more sources
Frontiers in Endocrinology, 2022 Thyroid hormones, T3 (triiodothyronine) and T4 (thyroxine), induce a variety of long-term effects on important physiological functions, ranging from development and growth to metabolism regulation, by interacting with specific nuclear or cytosolic ...
Sandra Incerpi +20 more
doaj +1 more source
Life Without Thyroid Hormone Receptor [PDF]
Endocrinology, 2021 Abstract Thyroid hormone (T3) is critical not only for organ function and metabolism in the adult but also for animal development. This is particularly true during the neonatal period when T3 levels are high in mammals. Many processes during this postembryonic developmental period resemble those during amphibian metamorphosis.
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Ecotoxicology and Environmental Safety, 2023 Benzisothiazolinone (BIT), one of the most widely used antimicrobial agents in consumer products, has frequently been detected in the water environment. The present study was conducted to determine the adverse effects of BIT on the thyroid neuroendocrine
Sujin Lee +4 more
doaj +1 more source
Thyroxine-Thyroid Hormone Receptor Interactions [PDF]
Journal of Biological Chemistry, 2004 Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs alpha and beta) that bind triiodothyronine (T(3), 3,5,3'-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T(4), 3,5,3',5'-tetraiodo-l-thyronine) with lower affinity. T(4) contains a bulky 5' iodine group absent from T(3).
Sandler, Ben +10 more
openaire +3 more sources
Frontiers in Endocrinology, 2014 Cerebellum development is sensitive to thyroid hormone (TH) levels, as THs regulate neuronal migration, differentiation and myelination. Most effects of THs are mediated by the TH receptor (TR) isoforms TRb1, TRb2 and TRa1.
Larissa Costa Faustino +1 more
doaj +1 more source
Diseases, 2020 Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings.
Duaa Althumairy +6 more
doaj +1 more source
Oftalʹmologiâ, 2014 Purpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune ...
V. G. Likhvantseva +5 more
doaj +3 more sources
Discovery & development of small molecule allosteric modulators of glycoprotein hormone receptors
Frontiers in Endocrinology, 2015 Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid stimulating hormone (TSH) are heterodimeric proteins with a common subunit and hormone-specific subunit.
Selvaraj G Nataraja +2 more
doaj +1 more source