Results 141 to 150 of about 13,430 (194)
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Thyrotropin-releasing hormone receptors in gut tissues resemble pituitary receptors
Neuroscience Letters, 1986The relative order of activity of thyrotropin-releasing hormone (TRH) and various analogs in contracting the isolated guinea pig antrum and duodenum correlated with their potencies in activating thyroid-stimulating hormone (TSH) release. The action of TRH in both tissues was selectively antagonized by the putative pituitary TRH receptor antagonist ...
V J, Lotti +5 more
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Thyrotropin-Releasing Hormone-Receptor Interaction in GH3 Pituitary Cells*
Endocrinology, 1980The interaction between TRH and GH3 pituitary tumor cells was studied in monolayer cultures or membrane-containing fractions. In intact cells, the apparent dissociation constant (Kd) was approximately 10 nM, and the total number of binding sites was approximately 1.4 pmol/mg protein at temperatures of 0-37 C.
P M, Hinkle, D G, Lewis, T L, Greer
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autoregulation of rat adenohypophyseal thyrotropin-releasing hormone receptor
Life Sciences, 1982The possible mechanism of attenuation of thyrotropin response to exogenous thyrotropin-releasing hormone in vivo after repeated administrations of the releasing hormone has been studied. To this end, the effect of prolonged hormone treatment on the binding of hormone to its receptor in the anterior pituitary gland has been evaluated. The data show that
A, Banerji, C, Prasad
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Molecular and cellular biology of thyrotropin-releasing hormone receptors
Physiological Reviews, 1996Thyrotropin-releasing hormone (TRH) receptor (TRH-R) complementary DNAs have been cloned from several species. The deduced amino acid sequences are compatible with TRH-R being a seven-transmembrane-spanning G protein-coupled receptor. These complementary DNAs and reagents derived from them have permitted detailed study of TRH-R biology at the ...
M C, Gershengorn, R, Osman
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Molecular Cloning of a Functional Human Thyrotropin-Releasing Hormone Receptor
Biochemical and Biophysical Research Communications, 1993A cDNA encoding the human thyrotropin-releasing hormone receptor (hTRH-R) was isolated from a human brain cDNA library. Screening of 1.2 million clones resulted in 2 candidates. The largest clone contained TRH-R homologous sequences starting in the third transmembrane domain and included a long 3' untranslated sequence.
V, Matre +7 more
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Receptors for thyrotropin-releasing hormone (TRH) in rabbit spinal cord
Brain Research, 1983Specific binding of 3H-labeled [3-Me-His2]TRH ([3H]MeTRH) to membranes of rabbit spinal cord (thoracic) involved a homogeneous population of high-affinity sites (Kd = 2.7 +/- 0.17 (n = 5) nM, Bmax = 204 +/- 12(5) fmol/mg protein). TRH analogs competed for the binding in the following rank order of potency: MeTRH greater than TRH greater than TRH-Gly ...
N A, Sharif, D R, Burt
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Thyrotropin-releasing hormone and its receptor in glia
Glia, 2001The presence of thyrotropin-releasing hormone (Thyroliberin, TRH) and its receptor (TRH-R) in frozen coronal sections of the adult rat spinal cord and neonatal rat astroglial cultures was investigated by means of immunocytochemistry and Western blot using polyclonal antibodies generated against the hormone and monoclonal antibodies originated against ...
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Thyrotropin releasing hormone: Apparent receptor binding in retina
Experimental Eye Research, 1979Abstract Thyrotropin releasing hormone (TRH) binds with high affinity to sites on sheep retinal membranes. These sites closely resemble sheep pituitary receptors for TRH, as determined by direct comparison of binding in the two tissues. Specific [ 3 H]TRH binding in sheep pituitary and retina was measured relative to blanks containing 1 μ m [3-Me ...
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Receptors for Thyrotropin-Releasing Hormone on Rat Lactotropes and Thyrotropes
Thyroid, 1998Primary cultures of rat pituitary cells were stained with an antibody to the native thyrotropin-releasing hormone (TRH) receptor and with a bioactive, fluorescent analogue of TRH, Rhod-TRH. Rhod-TRH specifically stained 86% of lactotropes and 21% of nonlactotropes from primary pituitary cell cultures.
R, Yu, R, Ashworth, P M, Hinkle
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Characteristics of thyrotropin releasing hormone (TRH) receptors in rat brain
Peptides, 1982Characteristics of TRH-receptors were studied in the rat central nervous system (CNS). Ion species, pH and temperature importantly influenced TRH-receptor binding. Subcellular distribution of TRH-receptor binding revealed that synaptic membranes had the greatest percentage of total sites.
N, Ogawa +6 more
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