Results 151 to 160 of about 13,430 (194)
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Identification of thyrotropin-releasing hormone receptor in the rat testis
Neuropeptides, 1994We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis.
T, Satoh, P, Feng, U J, Kim, J F, Wilber
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Biochemistry, 1997
Thyrotropin-releasing hormone (TRH), like most small ligands, appears to bind within the seven transmembrane-spanning helices (TMs) of its G protein-coupled receptor (TRH-R). A role for the extracellular loops (ECLs) of TRH-R has not been established.
J H, Perlman +6 more
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Thyrotropin-releasing hormone (TRH), like most small ligands, appears to bind within the seven transmembrane-spanning helices (TMs) of its G protein-coupled receptor (TRH-R). A role for the extracellular loops (ECLs) of TRH-R has not been established.
J H, Perlman +6 more
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Solubilization and characterization of pituitary thyrotropin-releasing hormone receptors.
Molecular Pharmacology, 1989Thyrotropin-releasing hormone (TRH) receptors were solubilized from a rat pituitary tumor cell line, GH4C1, with digitonin. Convenient assays were developed based on the ability of hydroxylapatite and polyethyleneimine-soaked glass fiber filters to adsorb the solubilized [3H]methyl-TRH-receptor complex but not free [3H]methyl-TRH.
W J, Phillips, P M, Hinkle
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Thyrotropin-Releasing Hormone: Analogs and Receptors
1993Publisher Summary Thyrotropin-releasing hormone (TRH) is a tripeptide ( p -Glu-His-Pro-NH 2 ) found in high concentrations in the mammalian central nervous system (CNS) and pituitary that has both neurotransmitter and neuroendocrine roles. In the CNS, TRH stimulates neuronal excitability; enhances amine and cholinergic transmitter turnover; and ...
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Endocrinology, 1977
The effect of estradiol and thyroid hormone treatment on pituitary TRH binding and TSH and PRL responses to the neurohormone was studied. A significant increase in the number of pituitary TRH binding sites was observed between 2 and 4 days after daily administration of estradiol benzoate with a plateau at 300% of control being reached at 7 days. Plasma
A D, Léan +4 more
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The effect of estradiol and thyroid hormone treatment on pituitary TRH binding and TSH and PRL responses to the neurohormone was studied. A significant increase in the number of pituitary TRH binding sites was observed between 2 and 4 days after daily administration of estradiol benzoate with a plateau at 300% of control being reached at 7 days. Plasma
A D, Léan +4 more
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[Radio-receptor assay for thyrotropin releasing hormone (author's transl)].
Annales d'endocrinologie, 1977The high affinity receptor for TRH of a rat pituitary GH3 strain in culture (Km: 4 X 10(-9) M) was found suitable to design a radio-receptor assay for TRH. Attached GH3 cells were incubated for 30 min at 37 degrees C in presence of a tracer amount of 3H-TRH (200 pg/ml, 0.54 nM) and increasing quantities of cold synthetic TRH.
A, Faivre-Bauman +2 more
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Distribution of thyrotropin-releasing hormone receptor mRNA in rat peripheral tissues
Regulatory Peptides, 1995Since the thyrotropin-releasing hormone receptor (TRH-R) cDNA was isolated, the distribution of TRH-R mRNA has been investigated in the central nervous system (CNS) and the pituitary. However, there has been less genetical studies on the distribution of TRH-R mRNA in the peripheral tissues, although TRH exists not only in CNS but also in the peripheral
S, Fukusumi, K, Ogi, H, Onda, S, Hinuma
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Thyrotropin-releasing hormone (TRH): Apparent receptor binding in rat spinal cord
Brain Research, 1984Thyrotropin-releasing hormone (TRH) is unevenly distributed throughout the rat central nervous system including spinal cord, where exogenous TRH elicits profound pharmacological effects. [Pro-3H]TRH binds to 30,000 g pellet fraction from the spinal cord saturably, reversibly, and with high affinity (apparent Kd = 24-25 nM). This binding is displaced by
C, Prasad, R M, Edwards
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Nihon rinsho. Japanese journal of clinical medicine, 1994
1) We successfully cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron in the coding sequence. Although highly homologous to the rat and mouse TRH-Rs, the human TRH-R has several differences in the carboxyl ...
M, Yamada, M, Mori
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1) We successfully cloned a human thyrotropin-releasing hormone receptor (TRH-R) gene. The human TRH-R consists of 398 amino acids and is a member of the G protein-coupled receptor family. The gene has a single intron in the coding sequence. Although highly homologous to the rat and mouse TRH-Rs, the human TRH-R has several differences in the carboxyl ...
M, Yamada, M, Mori
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Brain and Pituitary Receptors for Thyrotropin-Releasing Hormone in Hypothyroid Rats
Pharmacology, 1989The effect of hypothyroidism on the thyrotropin-releasing hormone (TRH) receptors in several brain regions and pituitary of rats was determined. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). Hypothyroidism was induced in male Sprague-Dawley rats by administering methimazole (0.05% w/v) in drinking water for 32 days.
H N, Bhargava +4 more
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