Results 181 to 190 of about 9,959 (228)

Thyrotoxicosis in MCT8 deficiency.

J Clin Endocrinol Metab
Boelaert K, Bauer A, Bauer A, Cappola AR, Chatterjee K, Dietrich JW, Nicol L, Persani L, Razvi S, Stoupa A.   +9 more
europepmc   +1 more source

Molecular and cellular biology of thyrotropin-releasing hormone receptors

Physiological Reviews, 1996
Thyrotropin-releasing hormone (TRH) receptor (TRH-R) complementary DNAs have been cloned from several species. The deduced amino acid sequences are compatible with TRH-R being a seven-transmembrane-spanning G protein-coupled receptor. These complementary DNAs and reagents derived from them have permitted detailed study of TRH-R biology at the ...
M C, Gershengorn, R, Osman
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Solubilization of pituitary receptors for thyrotropin-releasing hormone

Biochimica et Biophysica Acta (BBA) - General Subjects, 1978
Receptors for thyrotropin-releasing hormone were solubilized by Triton X-100. Membrane fractions from GH3 pituitary tumor cells were incubated with thyrotropin-releasing hormone in order to saturate specific receptor sites before the addition of detergent.
P M, Hinkle, D G, Lewis
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Role of the Extracellular Loops of the Thyrotropin-Releasing Hormone Receptor:  Evidence for an Initial Interaction with Thyrotropin-Releasing Hormone

Biochemistry, 1997
Thyrotropin-releasing hormone (TRH), like most small ligands, appears to bind within the seven transmembrane-spanning helices (TMs) of its G protein-coupled receptor (TRH-R). A role for the extracellular loops (ECLs) of TRH-R has not been established.
J H, Perlman, A O, Colson, R, Jain, B, Czyzewski, L A, Cohen, R, Osman, M C, Gershengorn   +6 more
openaire   +2 more sources

Identification of thyrotropin-releasing hormone receptor in the rat testis

Neuropeptides, 1994
We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis.
T, Satoh, P, Feng, U J, Kim, J F, Wilber
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Receptors for Thyrotropin-Releasing Hormone on Rat Lactotropes and Thyrotropes

Thyroid, 1998
Primary cultures of rat pituitary cells were stained with an antibody to the native thyrotropin-releasing hormone (TRH) receptor and with a bioactive, fluorescent analogue of TRH, Rhod-TRH. Rhod-TRH specifically stained 86% of lactotropes and 21% of nonlactotropes from primary pituitary cell cultures.
R, Yu, R, Ashworth, P M, Hinkle
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Ontogeny of receptors for thyrotropin-releasing hormone in the rat brain

Developmental Brain Research, 1986
Developmental changes in the thyrotropin-releasing hormone (TRH) receptor concentrations of hypothalamic and certain extrahypothalamic structures in the rat were evaluated from 2 days after birth until sexual maturity. The maturational pattern of TRH receptors in hypothalamus, striatum and amygdala follow that of the pituitary and all show the same ...
L, Blanchard, N, Barden
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Thyrotropin-releasing hormone and its receptor in glia

Glia, 2001
The presence of thyrotropin-releasing hormone (Thyroliberin, TRH) and its receptor (TRH-R) in frozen coronal sections of the adult rat spinal cord and neonatal rat astroglial cultures was investigated by means of immunocytochemistry and Western blot using polyclonal antibodies generated against the hormone and monoclonal antibodies originated against ...
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autoregulation of rat adenohypophyseal thyrotropin-releasing hormone receptor

Life Sciences, 1982
The possible mechanism of attenuation of thyrotropin response to exogenous thyrotropin-releasing hormone in vivo after repeated administrations of the releasing hormone has been studied. To this end, the effect of prolonged hormone treatment on the binding of hormone to its receptor in the anterior pituitary gland has been evaluated. The data show that
A, Banerji, C, Prasad
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Thyrotropin-releasing hormone and its receptors — A hypothesis for binding and receptor activation

Pharmacology & Therapeutics, 2007
Thyrotropin-releasing hormone (TRH), a tripeptide, exerts its biological effects through stimulation of cell-surface receptors, TRH-R, belonging to the superfamily of G protein-coupled receptors (GPCR). Because of the intermediate size of TRH, it is smaller than polypeptide ligands that interact at GPCR ectodomains and larger than biogenic amines ...
Stanislav, Engel, Marvin C, Gershengorn
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