Results 81 to 90 of about 9,959 (228)

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, Volume 41, Issue 7, Page 416-458, July 2026.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons.

, 2009
Hypophysiotropic TRH-synthesizing neurons of the hypothalamic paraventricular nucleus (PVN) have a critical role in the regulation of the energy homeostasis through control of the hypothalamic-pituitary-thyroid axis.
Wittmann, Gábor, Fekete, Csaba, Liposits, Zsolt, Watanabe, Masahiko, Deli, Levente, Lechan, Ronald M., Kalló, Imre   +6 more
core  

TG Nonsense Variant in Dwarf Rottweiler Dogs

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT We identified a dwarfism syndrome in six Rottweiler dogs characterized by reduced height and body weight; limb deformities, shortening of the tail and abnormally thick skin in puppies; developmental delays, pain and non‐goitrous hypothyroidism. Histological examination of the thyroid gland revealed severe chronic diffuse bilateral atrophy with
Marie Abitbol, Michaela Drögemüller, Cleo Schwarz, Etienne Furthner, Eva Dervas, Felicitas S. Boretti, Nadja S. Sieber‐Ruckstuhl, Caroline Dufaure de Citres, Chloé Pauchard, Vidhya Jagannathan, Tosso Leeb   +10 more
wiley   +1 more source

Sex‐ and Region‐Specific Glial Reactivity in Hyperthyroid Mice Lacks Correlation With the Noncognitive and Non‐Depressive‐Like Behavioral Alterations

Brain and Behavior, Volume 16, Issue 6, June 2026.
Hyperthyroidism induces sex‐ and region‐specific glial reactivity without correlation to the noncognitive, non‐depressive behavioral changes in mice. ABSTRACT Background Glial reactivity is implicated in hyperthyroidism‐associated cognitive and psychiatric disorders, yet in vivo imaging evidence of glial reactivity in hyperthyroidism remains to be ...
Qianqian Xue, Zefang Lin, Yaofeng Wang, Xiuting Lin, Yun Yang, Chao Wang, Yuhong Ye, Weibing Miao   +7 more
wiley   +1 more source

Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor

, 2008
Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
core  

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines [PDF]

, 2011
Breakthrough Breast CancerBackground: Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells.
Sims Andrew H, Faratian Dana, Miller, Nicola, Sims, Andrew H., Morgan, Kevin, Miller Nicola, Millar, Robert P., Langdon, Simon P., Ilgin Cagnan, Sims, Andrew, Dana Faratian, Robert P Millar, Meyer, Colette, Simon P Langdon, Colette Meyer, Harrison David J, Cagnan, Ilgin, Nicola Miller, Morgan Kevin, Millar Robert P, David J Harrison, Faratian, Dana, Langdon Simon P, Kevin Morgan, Meyer Colette, Cagnan Ilgin, Andrew H Sims, Harrison, David J.   +27 more
core   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Cloning and characterisation of gonadotropin-releasing hormone (GnRH) receptors in the cichlid (Haplochromis burtoni) and the zebrafish (Danio rerio)

, 2003
Bibliography: leaves 75-89.The identification of multiple forms of gonadotropin-releasing hormone (GnRH) in a single species is becoming a common occurrence.
Morley, Michelle Gaye
core  

Thyrotropin-releasing hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

, 2019
Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature as recommended by NC-IUPHAR [13]) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [28].
Gershengorn, Marvin, Davenport, Anthony P., Hills, Rebecca   +2 more
core   +1 more source