Results 141 to 150 of about 594,054 (285)

Epitope‐dependent acute inhibition and potentiation of N‐methyl‐d‐aspartate receptors by GluN1 autoantibodies

The Journal of Physiology, EarlyView.
Abstract figure legend Patient‐derived monoclonal anti‐GluN1 autoantibodies applied via the pipette solution have acute effects on GluN1‐3a/GluN2A N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) in cell‐attached recordings. IgG #003‐102 (left, red), which binds to the R2 lobe of the amino‐terminal domain of the glycine‐binding GluN1 subunit of the ...
Shang Yang, Johanna Heckmann, Maximilian Zettner, Keiichi Hasegawa, Taha Abdulla, Shiqiang Gao, Stephan Steinke, Michael Hust, Harald Prüss, Hiro Furukawa, Christian Geis, Manfred Heckmann, Jing Yu‐Strzelczyk   +12 more
wiley   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone

, 1984
Cyclo(Histidyl-Proline) is a metabolite of thyrotropin-releasing hormone. It has been suggested that this peptide plays a role in regulating prolactin secretion in GH cells.
BATTAINI, FIORENZO MARIA, Peterkofsky, A., Dannies, PS   +2 more
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Brain and Cardiometabolic Effects of Major Weight Loss in People With Obesity: Preliminary Cohort Findings

Obesity Science &Practice, Volume 12, Issue 6, December 2026.
ABSTRACT Objective Given the overlap between obesity‐related metabolic and vascular abnormalities and Alzheimer's disease (AD) risk factors, it is critical to determine whether weight loss improves brain and cardiovascular health. This study examined whether ≥ 40% excess‐weight loss is associated with improvements in cardiometabolic risk, brain ...
Naomi L. Gaggi, Brian Hurwitz, Jennifer Bernal, Courtney O'Brien, Christine Ren‐Fielding, Holly Lofton, Jenny Chen, Aviezer Saperstein, Sang Han Lee, Yun‐Juan Chang, Kathy F. Yates, Els Fieremans, Ricardo Osorio, Antonio Convit   +13 more
wiley   +1 more source

Psychotic depression associated with Graves' disease: A case report on treatment prioritization

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Background Graves' disease can be accompanied by psychiatric symptoms, including affective and psychotic manifestations. When a well‐defined psychiatric syndrome occurs concurrently with a medical illness, determining whether it is directly attributable to the medical condition or represents an independent psychiatric disorder precipitated by ...
Ayumu Kocha, Aya Akaba, Nozomi Sawasaki, Shinobu Seno, Naoya Hara, Taro Minato, Atsuo Nakagawa, Hiroki Kocha   +7 more
wiley   +1 more source

Marine flatworms as windows into the evolution of bilaterian neuropeptide signalling. [PDF]

J Neuroendocrinol
Nakamura R, Hamada M, Bailly X, Sakamoto H, Sakamoto T.   +4 more
europepmc   +1 more source