Results 201 to 210 of about 10,411 (253)

Mutations of thyrotropin receptor gene

Journal of Molecular Medicine, 1997
Thyrotropin is the primary pituitary hormone which stimulates the growth and differentiation of thyroid cells. TSH binds a specific receptor present in the plasma membrane of thyroid cells and signals the G protein transducers, which activate different effectors, mainly adenyl cyclase and phospholipase C.
PORCELLINI, ANTONIO, FENZI G, AVVEDIMNETO EV   +2 more
openaire   +3 more sources

Autoantibodies to the Thyrotropin Receptor

Endocrine Reviews, 1988
This review considers recent developments in our understanding of the properties of TRAb, particularly measurement of the antibodies and their sites of action and synthesis. Two new assay methods have allowed considerable improvements in the sensitivity, specificity, precision, and ease of measuring TRAb.
B, Rees Smith, S M, McLachlan, J, Furmaniak   +2 more
openaire   +2 more sources

Experimental autoimmunity to thyrotropin receptor

Experimental and Clinical Endocrinology & Diabetes, 2009
Since the cloning of a full length cDNA encoding the thyrotropin receptor (TSHr), several laboratories have been actively trying to develop an optimal animal model to understand the pathogenesis of TSHr mediated autoimmune diseases and have made considerable progress.
S A, Patibandla, N M, Wagle, G S, Seetharamaiah, J L, Fan, J S, Dallas, B S, Prabhakar   +5 more
openaire   +2 more sources

Reactivity of Thyrotropin Receptor Autoantibodies with the Thyrotropin Receptor on Western Blots

Thyroid, 2001
Affinity purified recombinant human thyrotropin receptor (TSHR) was run on sodium dodecyl sulfate (SDS) gels and subjected to a renaturing and blotting procedure. Twenty sera from thyrotropin receptor autoantibodies (TRAb)-positive patients with a history of hyperthyroidism and 20 sera with high levels of TSH blocking activity were analyzed. Four of 20
M, Maruyama, J, Sanders, Y, Oda, A, Kiddie, J, Furmaniak, B, Rees Smith   +5 more
openaire   +2 more sources

POSITIVE REGULATION OF HUMAN THYROTROPIN RECEPTOR mRNA BY THYROTROPIN

The Journal of Clinical Endocrinology & Metabolism, 1991
We have assessed the influence of natural and recombinant thyrotropin (TSH) on mRNA specific for the human TSH receptor (TSHR) in normal and abnormal adult human thyroid monolayer cells. Using physiological concentrations of TSH (less than 100 mU/L), a marked increase in the level of TSHR mRNA was observed within 12 hours and reached a greater than ...
G K, Huber, E S, Concepcion, P N, Graves, T F, Davies   +3 more
openaire   +2 more sources

Thyrotropin Receptor Purification

1990
Thyroid stimulating hormone (thyrotropin, TSH) derived from the anterior pituitary gland exerts its action by binding to specific receptors on thyroid follicular cells (Moore and Wolff, 1974; Kotani et al., 1975; Amir et al., 1976; Rees Smith et al., 1977; Pekonen and Weintraub, 1979). Binding initiates a sequence of processes (including stimulation of
Petu J. Leedman, Leonard C. Harrison
openaire   +1 more source

Immunological of the Thyrotropin Receptor

Immunological Communications, 1976
Antibodies to the thyrotropin receptor appear to be responsible for hyperthyroidism in Graves' disease. The antibodies, described as thyroid-stimulating antibodies (TSAb) mimic the effects of thyrotropin (TSH) by binding to the TSH receptor and activating adenylate cyclase.
openaire   +2 more sources

Analysis of the Thyrotropin Receptor-Thyrotropin Interaction by Comparative Modeling

Thyroid, 2004
We have used the most advanced programs currently available to construct the first three-domain structure of the human thyrotropin receptor (TSHR) using comparative modeling. The model consists of a leucine-rich domain (LRD; amino acids 36-281; porcine ribonuclease inhibitor used as a template for modeling), a cleavage domain (CD; amino acids 282-409 ...
Ricardo, Núñez Miguel, Jane, Sanders, Jennifer, Jeffreys, Hilde, Depraetere, Michele, Evans, Tonya, Richards, Tom L, Blundell, Bernard, Rees Smith, Jadwiga, Furmaniak   +8 more
openaire   +2 more sources

Molecular Genetics of the Thyrotropin Receptor

Experimental and Clinical Endocrinology & Diabetes, 2009
Thyroid-stimulating hormone (TSH) receptor has been cloned by a strategy exploiting its belonging to the superfamily of G-protein-coupled receptors. Comparison with the luteinizing hormone and follicle-stimulating hormone receptors shows that the glycoprotein hormone receptors constitute a subfamily of G-protein-coupled receptors with a large ...
Vassart, Gilbert, Brabant, G, Costagliola, Sabine, Danguy, Dominique, Gérard, Claude, Libert, Frédérick, Ludgate, Marian, Maenhaut, Carine, Parmentier, Marc, Paschke, Ralf, Perret, Jason, Van Sande, Jacqueline, Dumont, Jacques Emile   +12 more
openaire   +2 more sources

Molecular Cloning of the Thyrotropin Receptor

Science, 1989
The pituitary hormone thyrotropin, or thyroid-stimulating hormone (TSH), is the main physiological agent that regulates the thyroid gland. The thyrotropin receptor (TSHR) was cloned by selective amplification with the polymerase chain reaction of DNA segments presenting sequence similarity with genes for G protein-coupled receptors. Out of
Parmentier, Marc, Libert, Frédérick, Maenhaut, Carine, Lefort, Anne, Gérard, Claude, Perret, Jason, Van Sande, Jacqueline, Dumont, Jacques, Vassart, Gilbert   +8 more
openaire   +2 more sources