Results 231 to 240 of about 594,054 (285)

The Thyrotropin Receptor in Thyroid Diseases

New England Journal of Medicine, 1997
The growth and function of the thyroid are controlled by thyrotropin1 through the activation of its receptor, which belongs to the large family of G protein–coupled receptors.
Marian Ludgate, Ralf Paschke
exaly   +3 more sources

Reactivity of Thyrotropin Receptor Autoantibodies with the Thyrotropin Receptor on Western Blots

Thyroid, 2001
Affinity purified recombinant human thyrotropin receptor (TSHR) was run on sodium dodecyl sulfate (SDS) gels and subjected to a renaturing and blotting procedure. Twenty sera from thyrotropin receptor autoantibodies (TRAb)-positive patients with a history of hyperthyroidism and 20 sera with high levels of TSH blocking activity were analyzed. Four of 20
M, Maruyama, J, Sanders, Y, Oda, A, Kiddie, J, Furmaniak, B, Rees Smith   +5 more
openaire   +2 more sources

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

Thyroid, 1999
Thyrotropin receptor autoantibodies (TRAb) are most commonly measured in a thyrotropin-binding inhibition (TBI) assay using solubilized porcine thyrotropin receptors (pTSHR). Recently, we reported modifications in recombinant human thyrotropin receptor (hTSHR) production and extraction that made substitution of this antigen for the pTSHR practical.
A, Kakinuma, I, Morimoto, T, Kuroda, T, Fujihira, S, Eto, S M, McLachlan, B, Rapoport   +6 more
openaire   +2 more sources

Thyrotropin Receptors and Gangliosides

1980
Recent studies (1, 2, 28–30, 33–35) have implicated ganglio-sides in the receptor recognition process for thyrotropin (TSH) and have led to the hypothesis (15–17, 19) that the TSH receptor is structurally and functionally related to receptors for other ligands which interact with gangliosides in vitro, i.e., cholera toxin, tetanus toxin, and interferon.
L D, Kohn, E, Consiglio, M J, DeWolf, E F, Grollman, F D, Ledley, G, Lee, N P, Morris   +6 more
openaire   +2 more sources

The Influence of Propranolol on the Thyrotropin Receptor

Endocrinology, 1977
Propranolol, a beta adrenergic blocking drug, is known to inhibit the thyrotropin (TSH) stimulation of adenosine-3',5'-monophosphate (cyclic AMP production in thyroid membranes but the mechansim of this inhibitory action is known. We have therefore investigated the influence of propranolol on the binding of 125I-labelled TSH to human thyroid membranes.
T F, Davies, S M, McLachlan, P M, Povey, B R, Smith, R, Hall   +4 more
openaire   +2 more sources

Thyrotropin Receptor Antibodies in Early Pregnancy

The Journal of Clinical Endocrinology & Metabolism, 2022
Abstract Context Thyrotropin (TSH) receptor antibodies (TRAb) are important when distinguishing between Graves’ and gestational hyperthyroidism, but sparse evidence exists on the recommended cutoff during pregnancy.
Nanna Maria Uldall Torp, Niels Henrik Bruun, Peter Astrup Christensen, Aase Handberg, Stig Andersen, Stine Linding Andersen   +5 more
openaire   +3 more sources

Analysis of the Thyrotropin Receptor-Thyrotropin Interaction by Comparative Modeling

Thyroid, 2004
We have used the most advanced programs currently available to construct the first three-domain structure of the human thyrotropin receptor (TSHR) using comparative modeling. The model consists of a leucine-rich domain (LRD; amino acids 36-281; porcine ribonuclease inhibitor used as a template for modeling), a cleavage domain (CD; amino acids 282-409 ...
Ricardo, Núñez Miguel, Jane, Sanders, Jennifer, Jeffreys, Hilde, Depraetere, Michele, Evans, Tonya, Richards, Tom L, Blundell, Bernard, Rees Smith, Jadwiga, Furmaniak   +8 more
openaire   +2 more sources

Thyrotropin Receptor

1990
This paper deals with the isolation, purification and functional characterization of the TSH receptor.
Akamizu T., DE LUCA, Michele, Kohn L. D.
openaire   +2 more sources

Molecular Genetics of the Thyrotropin Receptor

Experimental and Clinical Endocrinology & Diabetes, 2009
Thyroid-stimulating hormone (TSH) receptor has been cloned by a strategy exploiting its belonging to the superfamily of G-protein-coupled receptors. Comparison with the luteinizing hormone and follicle-stimulating hormone receptors shows that the glycoprotein hormone receptors constitute a subfamily of G-protein-coupled receptors with a large ...
Vassart, Gilbert, Brabant, G, Costagliola, Sabine, Danguy, Dominique, Gérard, Claude, Libert, Frédérick, Ludgate, Marian, Maenhaut, Carine, Parmentier, Marc, Paschke, Ralf, Perret, Jason, Van Sande, Jacqueline, Dumont, Jacques Emile   +12 more
openaire   +3 more sources

Bioassays for thyrotropin receptor autoantibodies

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
Bioassays using animal models were essential tools in the discovery of thyrotropin and in enhancing our understanding of the physiology of the pituitary-thyroid axis. These same bioassays were also instrumental in the discovery of autoantibodies to the thyrotropin receptor (TSH-R-Ab) and in identifying their role in the pathophysiology of Graves ...
openaire   +2 more sources