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Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis [PDF]
Advanced Drug Delivery Reviews, 1994 Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of most proliferating cells, in elevated numbers on erythroblasts and
Ernst Wagner +2 more
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Annual Review of Medicine, 1993
The transferrin receptor plays a critical role in iron metabolism by precisely contrOlling the flow of transferrin iron into body cells. A soluble truncated form of the receptor can be detected in human serum using sensitive immunoassays, and the initial clinical experience with this new measurement indicates that it reflects the total body mass of ...
J D, Cook, B S, Skikne, R D, Baynes
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The transferrin receptor plays a critical role in iron metabolism by precisely contrOlling the flow of transferrin iron into body cells. A soluble truncated form of the receptor can be detected in human serum using sensitive immunoassays, and the initial clinical experience with this new measurement indicates that it reflects the total body mass of ...
J D, Cook, B S, Skikne, R D, Baynes
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Erythropoiesis and transferrin receptors
Current Opinion in Hematology, 2015The type 1 transferrin receptor (TfR1) is well known as a key player in erythroid differentiation through its role in iron uptake. Recently, it has been demonstrated that TfR1 could also have signaling functions in erythroid cells. Moreover, the second transferrin receptor, TfR2, whose signaling functions in hepatic cells are well established, was ...
Ivan C, Moura +3 more
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The role of the transferrinâtransferrin-receptor system in drug delivery and targeting
Trends in Pharmacological Sciences, 2002 Exploration of the potential of site-specific and target-oriented drug delivery systems has gained interest recently. Indeed, the efficient cellular mechanism of transferrin uptake has been exploited for the delivery not only of anticancer drugs and ...
Hongzhe Sun, Zhong Ming Qian
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American Journal of Hematology, 2008
AbstractTransferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under ironâdeficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.
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AbstractTransferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under ironâdeficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.
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Trends in Biochemical Sciences, 1982
Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Lymphoid receptors for transferrin
1987Publisher Summary Transferrin receptors present on the cell surface interact with this serum protein and provide a way in which iron can be specifically and vectorially transported through the plasma membrane. The transferrin receptor has proved to be an extremely useful system for the characterization of ligand/receptor interactions, receptor ...
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Relationship between Soluble Transferrin Receptors in Serum and Membrane-Bound Transferrin Receptors
Acta Haematologica, 1998The expression of transferrin receptors on the cell membrane of erythroblasts was analysed with flow cytometry in patients with different forms of anaemia. At the same time the concentration of soluble transferrin receptors (sTfRs) was analysed in serum. It was shown that only in iron deficiency a high concentration of sTfRs in serum could be explained
Kuiper -Kramer, PA +5 more
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Bacterial transferrin and lactoferrin receptors
Trends in Microbiology, 1996Pathogenic members of the Neisseriaceae and Pasteurellaceae express outer-membrane receptor proteins involved in the direct assimilation of iron from the host glycoproteins transferrin and lactoferrin. The critical requirement of iron for growth suggests that this function is an important component of colonization and infection. A model describing this
S D, Gray-Owen, A B, Schryvers
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The Transferrin Receptor and the Release of Iron from Transferrin
1994In a classic report detailing the role of transferrin in providing iron to human reticulocytes, Jand1 and coworkers noted that uptake of transferrin-borne iron was saturable as the concentration of transferrin in the culture medium increased, and that uptake was essentially abolished if cells were first exposed to trypsin.
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