Results 211 to 220 of about 48,638 (261)
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American Journal of Hematology, 2008
AbstractTransferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under iron‐deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.
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AbstractTransferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under iron‐deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.
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Erythropoiesis and transferrin receptors
Current Opinion in Hematology, 2015The type 1 transferrin receptor (TfR1) is well known as a key player in erythroid differentiation through its role in iron uptake. Recently, it has been demonstrated that TfR1 could also have signaling functions in erythroid cells. Moreover, the second transferrin receptor, TfR2, whose signaling functions in hepatic cells are well established, was ...
Ivan C, Moura +3 more
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Diferric transferrin regulates transferrin receptor 2 protein stability
Blood, 2004AbstractTransferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf). Mutations in TfR2 cause one form of hereditary hemochromatosis, a disease in which excessive absorption of dietary iron can lead to liver cirrhosis, diabetes, arthritis, and heart failure. The function of TfR2 in iron
Martha B, Johnson, Caroline A, Enns
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Relationship between Soluble Transferrin Receptors in Serum and Membrane-Bound Transferrin Receptors
Acta Haematologica, 1998The expression of transferrin receptors on the cell membrane of erythroblasts was analysed with flow cytometry in patients with different forms of anaemia. At the same time the concentration of soluble transferrin receptors (sTfRs) was analysed in serum. It was shown that only in iron deficiency a high concentration of sTfRs in serum could be explained
Kuiper -Kramer, PA +5 more
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Trends in Biochemical Sciences, 1982
Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Abstract The isolation and analysis of the transferrin receptor has been greatly aided by the use of monoclonal antibodies. The receptor is a disulphide-linked homo-dimer which spans the membrane and binds two molecules of transferrin. Controlling genes for this receptor in humans have been mapped to chromosome 3 using cell hybrids.
Roland Newman +4 more
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Diffusion of transferrin receptor clusters
Biophysical Chemistry, 1998Two dimensional motion of membrane receptors provides a mechanism for interaction among receptors in the plane of the membrane. In some cases the lateral diffusion leads to formation of clusters which may also be mobile. We have used image cross-correlation (ICCS) spectroscopy technique to measure the translational motion of transferrin receptors in ...
M, Srivastava, N O, Petersen
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Bacterial transferrin and lactoferrin receptors
Trends in Microbiology, 1996Pathogenic members of the Neisseriaceae and Pasteurellaceae express outer-membrane receptor proteins involved in the direct assimilation of iron from the host glycoproteins transferrin and lactoferrin. The critical requirement of iron for growth suggests that this function is an important component of colonization and infection. A model describing this
S D, Gray-Owen, A B, Schryvers
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Transferrin receptor in oral tumors
International Journal of Oral and Maxillofacial Surgery, 1994The transferrin receptor (TfR) appears in vigorously proliferating cells. We did an immunohistochemical study of TfR in oral tissues and a quantitative analysis by flow cytometry of TfR in a cancer cell line after an anticancer drug treatment. TfR was found in the parabasal and basal layers of the normal epithelium, but rarely in benign tumors ...
T, Miyamoto +3 more
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Lymphoid receptors for transferrin
1987Publisher Summary Transferrin receptors present on the cell surface interact with this serum protein and provide a way in which iron can be specifically and vectorially transported through the plasma membrane. The transferrin receptor has proved to be an extremely useful system for the characterization of ligand/receptor interactions, receptor ...
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Transferrin receptor: Its biological significance
The Journal of Membrane Biology, 1985The TR is a vital surface component which has been demonstrated to be involved in processes critical for cell metabolism and growth. This review has attempted to briefly touch on the more well understood aspects of study of the TR. These aspects include the biochemical characterization of the TR and the functional studies concerning the central role of
W S, May, P, Cuatrecasas
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