Results 61 to 70 of about 89,614 (169)

Pro‐tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma

open access: yesJournal of Veterinary Internal Medicine, 2014
Background Transforming growth factor beta 1 (TGFβ1) is a pleiotropic cytokine that contributes to reparative skeletal remodeling by inducing osteoblast proliferation, migration, and angiogenesis.
R.F. Portela   +7 more
doaj   +1 more source

The Role of the TGF-β Coreceptor Endoglin in Cancer

open access: yesThe Scientific World Journal, 2010
Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling.
Eduardo Pérez-Gómez   +5 more
doaj   +1 more source

Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease

open access: yesKorean Journal of Pediatrics, 2012
Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide polymorphisms (SNPs) of this gene are associated with Marfan syndrome and sudden death in patients with coronary artery disease.
Yu Mi Choi   +6 more
openaire   +3 more sources

Transforming growth factor-beta receptor expression in human cornea.

open access: yesInvestigative ophthalmology & visual science, 1997
Limbal basal cells and corneal endothelial cells appear to be inhibited in the G1 phase of the cell cycle. As a preliminary to determining whether transforming growth factor-beta (TGF-beta) might mediate this inhibition, investigation was made to determine whether human corneal and limbal cells express TGF-beta receptor types I (RI), II (RII), and III (
N C, Joyce, J D, Zieske
openaire   +1 more source

LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways

open access: yesCommunications Biology
Adult Neural Stem Cells (aNSCs) in the ventricular-subventricular zone (V-SVZ) are largely quiescent. Here, we characterize the mechanism underlying the functional role of a cell-signalling inhibitory protein, LRIG1, in the control of aNSCs proliferation.
Stephanie Ouzikov   +10 more
doaj   +1 more source

Transforming growth factor-beta superfamily members in the pathogenesis of pulmonary arterial hypertension [PDF]

open access: yesScripta Medica, 2012
Pulmonary arterial hypertension (PAH) is a devastating and rapidly progressing disease that induces substantial pulmonary vascular remodeling. The pathologic changes especially in pulmonary microvasculature result in progressive increases in the mean ...
Jerkić Mirjana
doaj  

Functional Analysis of Transforming Growth Factor-.BETA. type II Dominant Negative Receptor.

open access: yesTHE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1996
The transforming growth factor-beta (TGF-beta) is a multifunctional homodimeric protein with an apparent molecular weight of 25 KDa. TGF-beta transduces signals by forming heteromeric complexes of their type-I (T beta R-I) and type-II (T beta R-II) serin/threonine kinase receptors.
openaire   +3 more sources

El factor de crecimiento transformante beta como blanco terapéutico Transforming growth factor-beta as a therapeutic target

open access: yesSalud Pública de México, 2004
El factor de crecimiento transformante beta (TGF-beta) es una familia de proteínas que incluye al TGF-beta, activinas y a la proteína morfogénica de hueso (BMP, por sus siglas en inglés), citocinas que son secretadas y se relacionan estructuralmente en ...
Francisco Javier Gálvez-Gastélum   +2 more
doaj  

Blocking transforming growth factor-beta receptor signaling down-regulates transforming growth factor-beta1 autoproduction in keloid fibroblasts.

open access: yesChinese journal of traumatology = Zhonghua chuang shang za zhi, 2002
To study transforming growth factor-beta1 (TGF-beta1) autoproduction in keloid fibroblasts and the regulation effect of blocking TGF-beta intracellular signaling on rhTGF-beta1 autoproduction.Keloid fibroblasts cultured in vitro were treated with either rhTGF-beta1 (5 ng/ml) or recombinant adenovirus containing a truncated type II TGF-beta receptor ...
Wei, Liu   +7 more
openaire   +1 more source

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