Results 11 to 20 of about 5,796,978 (304)

Serum levels of tumor necrosis factor-like cytokine 1A and its receptors, death receptor 3 and decoy receptor 3, in patients with spondyloarthropathies: preliminary results from a cross-sectional study

Rheumatology
Introduction Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) is a member of the TNF superfamily of cytokines, involved in regulation of the immune and inflammatory response. Recently, therapies aimed at blockade of the TL1A pathway have shown benefit
Emilia Anna Frąckiel, Adrianna Błahuszewska-Omyła, Paweł Bielecki, Magdalena Bagrowska, Natalia Szymańska, Krzysztof Kowal, Otylia Kowal-Bielecka   +6 more
doaj   +2 more sources

Comparative Analysis of TNF-alpha, TNF-R1, and TNF-R2 in Patients with Low-impact Fractures Due to Osteoporosis [PDF]

Revista Brasileira de Ortopedia, 2023
Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted
Abel Oliveira Marques Teixeira, Virmondes Rodrigues-Júnior, Bárbara Rocha Rodrigues, Danila Malheiros Souza, Leonardo Franco Pinheiro Gaia, Denise Bertulucci Rocha Rodrigues   +5 more
doaj   +1 more source

Complement 1q/Tumor Necrosis Factor-Related Proteins (CTRPs): Structure, Receptors and Signaling

Biomedicines, 2023
Adiponectin and the other 15 members of the complement 1q (C1q)/tumor necrosis factor (TNF)-related protein (CTRP) family are secreted proteins composed of an N-terminal variable domain followed by a stalk region and a characteristic C-terminal ...
Constanze Schanbacher, Heike M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss [PDF]

Endocrinology and Metabolism, 2013
BackgroundReduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM)
Kwang Kon Kim, Sung Ho Jin, Byung Ju Lee
doaj   +1 more source

Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects

Frontiers in Immunology, 2020
Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its engagement of pleiotropic signaling via its two receptors: TNFR1 and
Portia Gough, Ian A. Myles
doaj   +1 more source

Basic characterization of antibodies targeting receptors of the tumor necrosis factor receptor superfamily

Frontiers in Immunology, 2023
Many new immunotherapeutic approaches aim on the stimulatory targeting of receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) using antibodies with intrinsic or conditional agonism.
Olena Zaitseva, Mohamed Anany, Mohamed Anany, Harald Wajant, Isabell Lang   +4 more
doaj   +1 more source

Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma

Frontiers in Immunology, 2022
Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence
Lidawani Lambuk, Suhana Ahmad, Muhammad Zulfiqah Sadikan, Nor Asyikin Nordin, Ramlah Kadir, Nurul Alimah Abdul Nasir, Xin Chen, Jennifer Boer, Magdalena Plebanski, Rohimah Mohamud   +9 more
doaj   +1 more source

Understanding the immunopathogenic bases and the clinical approach of the periodic syndrome associated with the tumor necrosis receptor, TRAPS

Iatreia, 2018
Tumor necrosis factor receptor periodic syndrome (TRAPS) is characterized by episodes of fever of more than 10 days of duration, migratory myalgias, pseudocellulitis, abdominal pain and bipalpebral edema.
Moreno Zuluaga, Catalina, Velásquez Lopera, Margarita María   +1 more
doaj   +1 more source

Comparison the function of Cyprinid herpesvirus 3 encoded two viral tumor necrosis factor receptors

Aquaculture Reports, 2021
To avoid immune surveillance and elimination from the host, many viruses encode homologues of host cytokines and cytokine receptors to regulate the host immune response.
Yaojia Zhou, Ping Ouyang, Yu Tao, Lizi Yin, Kaiyu Wang, Yi Geng, Weiming Lai, Defang Chen, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Xiaoli Huang   +12 more
doaj   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source