Results 211 to 220 of about 256,662 (267)

Silymarin attenuates diabetic nephropathy in rats via modulation of the miRNA-223/NLRP3/caspase-1/GSDMD axis and inflammasome-related pyroptotic signaling. [PDF]

Biol Direct
Aboismaiel MG, Amin MN, Eissa LA.
europepmc   +1 more source

Immune checkpoint blockade as an accelerator of adrenal aging: a testable model linking low-grade cortical inflammation to proteostasis failure, LDLR/SULT2A1 suppression, and reduced DHEA output. [PDF]

J Immunother Cancer
Ding G, Xu Y, Guo T, Feng C.
europepmc   +1 more source

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Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

Circulation, 1996
Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that produces negative inotropic effects in the heart. Recently, elevated levels of TNF-α have been reported in patients with advanced congestive heart failure.
Guillermo Torre-Amione, Samir Kapadia, Jean-Bernard Durand   +2 more
exaly   +3 more sources

The Tumor Necrosis Factor Ligand and Receptor Families

New England Journal of Medicine, 1996
Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on the basis of their ability to kill tumor cells in vitro and to cause hemorrhagic necrosis of transplantable tumors in mice.1 The complementary DNAs and genes encoding each protein were cloned immediately thereafter.2,3 Concurrently, a factor known as cachectin was ...
BAZZONI, Flavia, BEUTLER B.
openaire   +3 more sources

Immunobiology of Tumor Necrosis Factor Receptor Superfamily

Immunologic Research, 2002
The proteins of the tumor necrosis factor (TNF) receptor superfamily are a group of cell-surface receptors critically involved in the maintenance of homeostasis of the immune system. By interacting with their corresponding ligands, these receptors either induce cell death or promote cell survival of immune cells. The number of recognized members of the
Tong, Zhou, John D, Mountz, Robert P, Kimberly   +2 more
openaire   +2 more sources

Assay of Soluble Tumor Necrosis Factor Receptors

2003
Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1-4). One of the major insights that has emerged during recent years has been that under physiological circumstances, TNF activity is tightly ...
Boumaand, M.G., Buurman, W.A.
openaire   +3 more sources

Tumor necrosis factor receptors-structure and function

Immunologic Research, 1992
Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines.
J, Rothe, G, Gehr, H, Loetscher, W, Lesslauer   +3 more
openaire   +2 more sources

Signal transduction by tumor necrosis factor receptors

Cellular Signalling, 2012
Tumor necrosis factor (TNF) is a key mediator in the inflammatory response which is implicated in the onset of a number of diseases. Research on TNF led to the characterization of the largest family of cytokines known until now, the TNF superfamily, which exert their biological effects through the interaction with transmembrane receptors of the TNFR ...
Lucía, Cabal-Hierro, Pedro S, Lazo
openaire   +2 more sources