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3D Modeling of Tumor Necrosis Factor Receptor and Tumor Necrosis Factor‐bound Receptor Systems
Molecular Informatics, 2019AbstractThe interactions between the tumor necrosis factor (TNF) and its receptor molecule are responsible for various signaling networks that are central to the functioning of human immune homeostasis. The present work is a computational study of certain structural aspects of this cell‐signaling protein, specifically focusing on the molecular level ...
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Tumor necrosis factor receptors in the pituitary cells
Brain Research, 1997To clarify the site and mode of action of tumor necrosis factor (TNF) in the pituitary, we studied the effects, binding sites of TNF and its receptor mRNA in the two types of mouse pituitary-derived cell lines, AtT-20, ACTH-producing cells and TtT/GF, folliculo-stellate (FS)-like cells.
H, Kobayashi +9 more
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Veterinary Immunology and Immunopathology, 2004
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the tumor necrosis factor receptor (TNFR) superfamily. In this study, we cloned and characterized two genes that encode chicken TNFR-II and TRAF5.
Sayed Abdalla, Abdalla +3 more
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Tumor necrosis factor-? and tumor necrosis factor receptors in human heart failure
Heart Failure Reviews, 1996The basic mechanisms that are responsible for the development and progression of congestive heart failure are not known. Although clinicians have traditionally viewed heart failure as a hemodynamic disorder related to left ventricular pump dysfunction, one of the more recent concepts that has emerged is that the development and progression of heart ...
Biykem Bozkurt +4 more
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International Journal of Hematology, 2006
The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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The interactions between members of the tumor necrosis factor (TNF) family and their specific receptors (TNFRs) are influential in controlling cell division, life, and death. Recent evidence suggests that these interactions control the functionality and longevity of many types of cells involved in immune responses.
Takanori, So +2 more
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Tumor Necrosis Factor Receptors Encoded by Poxviruses
Molecular Genetics and Metabolism, 1999Poxviruses encode several cytokine response modifying (Crm) proteins. The Crm proteins possess sequence homology to several human proteins important in immunity. This homology and the conservation of Crm proteins among poxvirus strains suggest an immunomodulatory function that provides a survival advantage to the virus.
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The nerve growth factor/tumor necrosis factor receptor family
Journal of Leukocyte Biology, 1996Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin +3 more
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The p70 tumor necrosis factor receptor mediates cytotoxicity
Cell, 1992Tumor necrosis factor alpha (TNF) selectively kills tumor cells, but this specificity is not clearly understood. Two distinctly different cell surface receptors (TNFRs), proteins of 55 kd (p55) and 70-80 kd (p70), mediate TNF action. Mouse TA1 cells are not killed by human (h) TNF, but are killed by mouse (m) TNF alone.
R A, Heller, K, Song, N, Fan, D J, Chang
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Mechanisms controlling the level of receptors for tumor necrosis factor
Agents and Actions, 1991Udgivelsesdato: 1991 ...
Holtmann, H +6 more
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Regulation and dysregulation of tumor necrosis factor receptor-1
Cytokine & Growth Factor Reviews, 2014TNF is an essential regulator of the immune system. Dysregulation of TNF plays a role in the pathology of many auto-immune diseases. TNF-blocking agents have proven successful in the treatment of such diseases. Development of novel, safer or more effective drugs requires a deeper understanding of the regulation of the pro-inflammatory activities of TNF
Leen Puimège +2 more
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