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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Annual Review of Immunology, 1999▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTβR), and herpes virus entry mediator (HVEM) to control a wide range of innate and ...
D, Wallach +5 more
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The Role of Tumor Necrosis Factor-α Receptors in Atherosclerosis
Trends in Cardiovascular Medicine, 1998Tumor necrosis factor (TNF-α)-α is a cytokine exhibiting a plethora of activities involved in inflammation, immune regulation, and energy metabolism. TNF is produced by many cell types, including cells found in atherosclerotic lesions, such as activated monocytes or macrophages, T and B lymphocytes, mast cells, and smooth muscle cells.
R C, Leboeuf, S A, Schreyer
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Tumor necrosis factor receptor superfamily.
Journal of inflammation, 1997Tumor necrosis factor (TNF) is a powerful cytokine which is involved in the immune and pro-inflammatory response. The TNF receptors (TNF-R1 and TNF-R2) are the sole mediators of TNF signaling. The receptors consist of a disulfide rich domain which recognizes TNF, a transmembrane helix, and a cytoplasmic domain.
J H, Naismith, S R, Sprang
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Biological functions of tumor necrosis factor cytokines and their receptors
Cytokine & Growth Factor Reviews, 2003Tumor necrosis factor (TNF; formerly known as TNFalpha) and lymphotoxin (LT)alpha, originally characterized by their ability to induce tumor cell apoptosis and cachexia, are now considered as central mediators of a broad range of biological activities.
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Tumor necrosis factor: receptors and inhibitors.
Cancer cells (Cold Spring Harbor, N.Y. : 1989), 1991Tumor necrosis factor (TNF) is a highly potent pleiotropic response modifier in inflammatory and immunologic host defense reactions. It can also be toxic to cells and elicit toxic systemic reactions, as evinced by certain pathophysiologic conditions that are initiated or aggravated by an excess of TNF.
H, Loetscher, M, Steinmetz, W, Lesslauer
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Tumor necrosis factor family ligand–receptor binding
Current Opinion in Structural Biology, 2004Ligands and receptors of the tumor necrosis factor (TNF) superfamily have pivotal roles in the development and function of the immune system. The growing pool of data on TNF from structural and biochemical studies suggests that the higher order clustering of TNF family ligands could play an essential role in signal transduction initiation for this ...
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Tumor necrosis factor receptor superfamily members and their ligands
Current Opinion in Immunology, 1994The tumor necrosis factor (TNF) receptor family comprises a number of type I integral membrane glycoproteins which exhibit sequence homology in their cysteine-rich extracellular domains. Recently, ligands for many of these receptors have been identified.
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Soluble and cell surface receptors for tumor necrosis factor
1992Tumor necrosis factor (TNF) represents a remarkable example for the dichotomic nature which characterizes some molecules classified as cytokines. No other cytokine combines such enormous beneficial and detrimental potential. Discovered initially as a serum factor with dramatic antitumor effects [1], TNF eventually emerged as the mediator with a wide ...
H. Engelmann +6 more
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