Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha
Indian Journal of Ophthalmology, 2012 Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively
Renu Agarwal, Puneet Agarwal
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Death receptor 5 expression is inversely correlated with prostate cancer progression. [PDF]
, 2014 Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic
Antonio-Andres, Gabriela +10 more
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Pathogens and Dead Cells Cooperate with Cytokines in Activating the Innate and Adaptive Response
European Journal of Inflammation, 2011 After microbial invasion and tissue damage, a set of cytokines, including interleukin-1α (IL-1α), IL-1β, IL-6, IL-18 and tumor necrosis factor-α (TNF-α), and microbial and endogenous molecules named pathogen-associated molecular pattern (PAMPs) and ...
J.E. Belizário
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Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
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Tumor necrosis factor: receptors on hematopoietic cells [PDF]
Blood, 1987 Tumor necrosis factor (TNF) is a monokine that is cytotoxic/cytostatic for a variety of tumor cells and has multiple effects on normal cells. We demonstrate that normal and malignant human myeloid cells express a single class of high-affinity receptors (400 to 1,900 per cell, KD 20 to 90 pmol/L) for TNF.
R, Munker, J, DiPersio, H P, Koeffler
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Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice. [PDF]
PLoS ONE, 2012 Tumor necrosis factor-α (TNF-α) is a key factor for the pathogenesis of inflammatory bowel diseases (IBD), whose function is known to be mediated by TNF receptor 1 (TNFR1) or 2.
Ke Wang +13 more
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Differences in reactivation of tuberculosis induced from anti-tnf treatments are based on bioavailability in granulomatous tissue [PDF]
, 2007 The immune response to Mycobacterium tuberculosis (Mtb) infection is complex. Experimental evidence has revealed that tumor necrosis factor (TNF) plays a major role in host defense against Mtb in both active and latent phases of infection.
Denise E Kirschner +7 more
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PLoS ONE, 2022 BackgroundAlthough hyperinflammatory response influences the severity of coronavirus disease 2019 (COVID-19), little has been reported about the utility of tumor necrosis factor (TNF)-related biomarkers in reflecting the prognosis.
Tomohito Gohda +6 more
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Mechanisms of cell death in acute liver failure
Frontiers in Physiology, 2012 Acute liver failure (ALF) occurs when the extent of hepatocyte death exceeds the regenerative capacity of the liver. The mode of liver cell death that is predominantly induced in ALF, i.e.
Heike eBantel
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JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand. [PDF]
, 2009 Background: cJun terminal kinase (JNK) is constitutively activated in most hepatocellular carcinomas (HCCs), yet its exact role in carcinogenesis remains controversial.
Bruns, Christiane +10 more
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