Results 41 to 50 of about 4,110,019 (315)
mBio, 2016 Virus binding to the cell surface triggers an array of host responses, including activation of specific signaling pathways that facilitate steps in virus entry.
Samantha D. O’Hara, Robert L. Garcea
doaj +1 more source
Structural basis for human coronavirus attachment to sialic acid receptors
Nature Structural & Molecular Biology, 2019 Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host receptors and fuses the viral and cellular membranes.
M. A. Tortorici +10 more
semanticscholar +1 more source
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Comparative distribution of human and avian type sialic acid influenza receptors in the pig
BMC Veterinary Research, 2010 Background A major determinant of influenza infection is the presence of virus receptors on susceptible host cells to which the viral haemagglutinin is able to bind.
Perez Belinda +5 more
doaj +1 more source
Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022 Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers +7 more
wiley +1 more source
Viruses, 2018 Wild birds are the reservoir for low-pathogenic avian influenza viruses, which are frequently transmitted to domestic birds and occasionally to mammals. In 2014, an H10N7 virus caused severe mortality in harbor seals in northeastern Europe.
Anne Dittrich +6 more
doaj +1 more source
High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression. [PDF]
PLoS ONE, 2010 We investigated the genetics of Fc receptors, which function as activating receptors on immune cells and help to control HIV through antibody-mediated cellular cytotoxicity.
Bhawna Poonia +2 more
doaj +1 more source
The stochastic entry of enveloped viruses: Fusion vs. endocytosis [PDF]
Biophys. J., 93, 1116-1123, (2007), 2007 Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or ``spikes,'' on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization,
arxiv +1 more source
Role of Phosphatidylserine Receptors in Enveloped Virus Infection
Journal of Virology, 2014 We recently demonstrated that a soluble protein, Gas6, can facilitate viral entry by bridging viral envelope phosphatidylserine to Axl, a receptor tyrosine kinase expressed on target cells.
K. Morizono, I. Chen
semanticscholar +1 more source
Inspecting the interaction between HIV and the immune system through genetic turnover [PDF]
arXiv, 2022 Chronic infections of the human immunodeficiency virus (HIV) create a very complex co-evolutionary process, where the virus tries to escape the continuously adapting host immune system. Quantitative details of this process are largely unknown and could help in disease treatment and vaccine development.
arxiv