Results 101 to 110 of about 3,147,852 (168)
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Pharmacology and functions of metabotropic glutamate receptors.
Annual Review of Pharmacology and Toxicology, 1997In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins.
Conn Pj, J. Pin
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Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
Brain Research Reviews, 2008Future therapies for diseases associated with altered dopaminergic signaling, including Parkinson's disease, schizophrenia and drug addiction or drug dependence may substantially build on the existence of intramembrane receptor-receptor interactions within dopamine receptor containing receptor mosaics (RM; dimeric or high-order receptor oligomers ...
Fuxe K +14 more
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Reviews in the Neurosciences, 2016
AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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AbstractIntercellular and intracellular communication processes consist of signals and recognition/decoding apparatuses of these signals. In humans, the G protein-coupled receptor (GPCR) family represents the largest family of cell surface receptors.
Agnati, Luigi F. +4 more
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Pharmacological Reviews, 2002Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD:1:CB1:), cloned in 1990, and CB2(2.1:CBD:2:CB2:), cloned in 1993. Distinction between these receptors is based on differences in their predicted amino acid sequence, signaling ...
A. Howlett +11 more
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Receptor Regulation and Receptor-Receptor Communication
1987As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations.
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Bradykinin receptors and receptor ligands (with special emphasis on vascular receptors)
Regulatory Peptides, 1996Bradykinin and receptor ...
REGOLI, Domenico +7 more
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1992
Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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Publisher Summary This chapter presents the pharmacodynamics of drug-receptor interactions. Because of the low concentration of drugs and receptors in the bloodstream and other biological fluids, the law of the mass action alone cannot account for the ability of small doses of structurally specific drugs to elicit a total response.
Richard B. Silverman, Mark W. Holladay
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A decade of molecular biology of retinoic acid receptors
The FASEB Journal, 1996Retinoids play an important role in development, differentiation, and homeostasis. The discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated transcriptional regulators has revolutionized our molecular understanding as ...
P. Chambon
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The Physiology, Signaling, and Pharmacology of Dopamine Receptors
Pharmacological Reviews, 2011G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension ...
J. Beaulieu, R. Gainetdinov
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Pharmaceutica Acta Helvetiae, 2000
The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
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The identification of new binding sites raises the problem of defining their role, if any. At times they are shown to be pharmacological receptors, in a strict sense, as they fulfill certain requirements, and a precise physiological role and function, and an endogenous ligand (neurotransmitter) are discovered.
openaire +3 more sources