Results 101 to 110 of about 5,911,760 (307)

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]

open access: yes, 2012
Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core   +1 more source

Short‐chain mono‐carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand‐gated ion channel, and impact of a pre‐β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect

open access: yesPhysiological Reports
Using the bacterial proton‐activated pentameric receptor‐channel Gloeobacter violaceus ligand‐gated ion channel (GLIC): (1) We characterize saturated, mono‐carboxylates as negative modulators of GLIC (as previously shown for crotonate; Alqazzaz et al ...
Catherine Van Renterghem   +3 more
doaj   +1 more source

Not All Immune Checkpoints Are Created Equal

open access: yesFrontiers in Immunology, 2018
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares   +3 more
doaj   +1 more source

Pharmacology of Adenosine Receptors: The State of the Art.

open access: yesPhysiological Reviews, 2018
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea   +4 more
semanticscholar   +1 more source

Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice

open access: yesFrontiers in Pharmacology, 2019
Neuroinflammation is regarded as one of the pathogenic factors of Alzheimer disease (AD). Previously, we showed that mice regularly injected with bacterial lipopolysaccharide (LPS) possessed the AD-like symptoms like episodic memory decline, elevated ...
Olena Lykhmus   +11 more
doaj   +1 more source

Purinergic signalling: past, present and future [PDF]

open access: yes, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
Burnstock, G
core   +1 more source

Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

open access: yesFrontiers in Pharmacology, 2019
The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC).
Xiaobo Nie   +13 more
doaj   +1 more source

Specific receptors of fixed tissues [PDF]

open access: green, 1916
W. H. Manwaring, Yoshiki Kusama
openalex   +1 more source

Somatostatin receptors

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2003
In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event prompted the successful quest for SRIF receptors. Then, nearly a quarter of a century later, it was announced that a neuropeptide, to be named cortistatin (CST), had ...
Møller, Lars Neisig   +3 more
openaire   +2 more sources

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