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Elegant and Innovative Recoding Strategies for Advancing Vaccine Development [PDF]

Vaccines
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins.
François Meurens, Fanny Renois, Uladzimir Karniychuk   +2 more
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C to U RNA editing of MFN1 is regulated by ADARB1 and associates with favourable prognosis in chronic lymphocytic leukemia [PDF]

Scientific Reports
Cytidine to uridine (C-to-U) as well as adenosine to inosine (A-to-I) RNA editing denotes the posttranscriptional modification of RNA by specialized RNA deaminases.
Alejandra Gonzalez Martinez, Franz Josef Gassner, Dominik Baumgartner, Philine Hoven, Ekaterina Akimova, Markus Steiner, Stephanie Schlichtner, Stefanie Rauscher, Ferran Nadeu, Elias Campo, Richard Greil, Alexander Egle, Lisa Pleyer, Nadja Zaborsky, Roland Geisberger   +14 more
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Seeing the unseen in characterizing RNA editome during rice endosperm development [PDF]

Communications Biology
Rice (Oryza sativa L.) endosperm is essential to provide nutrients for seed germination and determine grain yield. RNA editing, a post-transcriptional modification essential for plant development, unfortunately, is not fully characterized during rice ...
Ming Chen, Lin Xia, Xinyu Tan, Shenghan Gao, Sen Wang, Man Li, Yuansheng Zhang, Tianyi Xu, Yuanyuan Cheng, Yuan Chu, Songnian Hu, Shuangyang Wu, Zhang Zhang   +12 more
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Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes.

PLoS Pathogens, 2023
Virus genome recoding is an attenuation method that confers genetically stable attenuation by rewriting a virus genome with numerous silent mutations. Prior flavivirus genome recoding attempts utilised codon deoptimisation approaches.
Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu   +15 more
doaj   +1 more source

Urban Shivers: Recoding Actual Space in Disco Elysium

Галактика медиа: журнал медиа исследований, 2022
The functioning of urban space in games is often passive, since the city acts as an object of observation, a scenery for the player’s actions. In the Disco Elysium game, the city receives its voice, soul, and will, which the player can observe by ...
Arina R. Medvedeva
doaj   +1 more source

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

mBio, 2023
Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias).
Nuri K. Hegelmeyer, Lia A. Parkin, Mary L. Previti, Joshua Andrade, Raditya Utama, Richard J. Sejour, Justin Gardin, Stephanie Muller, Steven Ketchum, Alisa Yurovsky, Bruce Futcher, Sara Goodwin, Beatrix Ueberheide, Jessica C. Seeliger   +13 more
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Programmed Deviations of Ribosomes From Standard Decoding in Archaea

Frontiers in Microbiology, 2021
Genetic code decoding, initially considered to be universal and immutable, is now known to be flexible. In fact, in specific genes, ribosomes deviate from the standard translational rules in a programmed way, a phenomenon globally termed recoding ...
Federica De Lise, Andrea Strazzulli, Andrea Strazzulli, Roberta Iacono, Roberta Iacono, Nicola Curci, Nicola Curci, Mauro Di Fenza, Luisa Maurelli, Marco Moracci, Marco Moracci, Marco Moracci, Beatrice Cobucci-Ponzano   +12 more
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SpaRec: Sparse Systematic RLNC Recoding in Multi-Hop Networks

IEEE Access, 2021
Sparse Random Linear Network Coding (RLNC) reduces the computational complexity of the RLNC decoding through a low density of the non-zero coding coefficients, which can be achieved through sending uncoded (systematic) packets.
Elif Tasdemir, Mate Tomoskozi, Juan A. Cabrera, Frank Gabriel, Dongho You, Frank H. P. Fitzek, Martin Reisslein   +6 more
doaj   +1 more source

MULTILINGUAL RECODING METHOD DESIGNED FOR SCADA-SYSTEM’S SOFTWARE UPGRADE

Автоматизация технологических и бизнес-процессов, 2017
The article discusses a new approach to upgrade the software  for SCADA-systems. A distinctive feature of this method is the ability to support more than ten most popular programming languages.
S. Velykodniy, O. Tymofieieva
doaj   +3 more sources

Transcript Regulation of the Recoded Archaeal α-l-Fucosidase In Vivo

Molecules, 2021
Genetic decoding is flexible, due to programmed deviation of the ribosomes from standard translational rules, globally termed “recoding”. In Archaea, recoding has been unequivocally determined only for termination codon readthrough events that regulate ...
Federica De Lise, Roberta Iacono, Andrea Strazzulli, Rosa Giglio, Nicola Curci, Luisa Maurelli, Rosario Avino, Antonio Carandente, Stefano Caliro, Alessandra Tortora, Fabio Lorenzini, Paola Di Donato, Marco Moracci, Beatrice Cobucci-Ponzano   +13 more
doaj   +1 more source