Results 51 to 60 of about 16,733 (160)

A Versatile Strategy to Reduce UGA-Selenocysteine Recoding Efficiency of the Ribosome Using CRISPR-Cas9-Viral-Like-Particles Targeting Selenocysteine-tRNA^[Ser]Sec Gene

Cells, 2019
The translation of selenoprotein mRNAs involves a non-canonical ribosomal event in which an in-frame UGA is recoded as a selenocysteine (Sec) codon instead of being read as a stop codon.
Caroline Vindry, Olivia Guillin, Philippe E. Mangeot, Théophile Ohlmann, Laurent Chavatte   +4 more
doaj   +1 more source

Recoding the Codon Usage of fis Gene of Pasteurella multocida with Rare Codons Reduces Pathogenicity

Journal of Pure and Applied Microbiology
Study was undertaken to evaluate gene recoding as an approach for vaccine development. Fis a transcriptional regulatory protein regulates the expression of more than 200 genes in different growth phases and at least 42 genes during exponential growth ...
Ajeet Kumar, Parthasarathi Behera, Muhammed Kutty, Prabhakar B. Ghorpade, Ajay Kumar, Bhaskar Sharma   +5 more
doaj   +1 more source

Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters

Bioengineering & Translational Medicine
Monoclonal antibodies (mAbs) are commonly used biologic therapeutics with a wide variety of clinical applications. During the development process, manufacturers consider different production parameters to improve protein yield and achieve appropriate ...
Nayiri M. Kaissarian, Stephanie L. Sandefur, Arnab Ghosh, Upendra K. Katneni, Wendy Walton, Christopher C. Frye, Anton A. Komar, Chava Kimchi‐Sarfaty   +7 more
doaj   +1 more source

Narrowing down the candidates of beneficial A-to-I RNA editing by comparing the recoding sites with uneditable counterparts

Nucleus
Adar-mediated adenosine-to-inosine (A-to-I) RNA editing mainly occurs in nucleus and diversifies the transcriptome in a flexible manner. It has been a challenging task to identify beneficial editing sites from the sea of total editing events.
Tianyou Zhao, Ling Ma, Shiwen Xu, Wanzhi Cai, Hu Li, Yuange Duan   +5 more
doaj   +1 more source

Reading time and formation of orthographic representation in Spanish

Revista de Psicología, 2019
The present study aimed to analyze whether the time children take to recode a word affects the ability to store the orthographic form of that word. For this, 40 third graders phonologically recoded orthographically complex pseudowords.
Marina Ferroni, Beatriz Diuk, Milagros Mena   +2 more
doaj  

Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene

Epigenetics
Although A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan   +6 more
doaj   +1 more source

iFAct Recoding

, 2009
Tese de mestrado integrado. Engenharia Informática e Computação. Faculdade de Engenharia.
openaire   +2 more sources

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in <i>Leishmania mexicana</i>. [PDF]

Front Cell Infect Microbiol
McNiven C, Carnielli Trindade JB, Geoghegan V, Faria JRC, Mottram JC.   +4 more
europepmc   +1 more source

How does AI perform compared to human expert panels in medical Delphi studies? A pilot study through the lens of pathology. [PDF]

J Pathol Inform
Pantanowitz J, Manko CD, Majewski J, Berbís MA, Farris AB, Karsan A, Bychkov A, Luna A, Williams B, Delahunt B, Eloy C, McClintock DS, Hollemans E, Tuthill JM, Van der Laak J, Cheng JY, Lennerz JK, Sinard JH, Aneiros-Fernandez J, Calderaro J, Iczkowski KA, Egevad L, Kriegsmann M, Herrmann MD, Salama ME, Del Moral RG, Sirintrapun SJ, Vrbin C, Pantanowitz L, Shen J, Rashidi H.   +30 more
europepmc   +1 more source

Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain. [PDF]

Nat Commun
Breen MS, Yang A, Wang X, Rodriguez de Los Santos M, Tao R, Weinberger DR, Kleinman JE, Mihova K, Stancheva G, Savova S, Kaneva R, Dimitrova V, Vladimirov V, Hyde TM, Buxbaum JD.   +14 more
europepmc   +1 more source