Results 111 to 120 of about 9,737,550 (145)

UDP-Glucose-P2Y14 Receptor Signaling Enhances the Responsiveness of Hematopoietic Stem/Progenitor Cells to Chemoattractants by Facilitating Membrane Lipid Raft Formation and Nlrp3 Inflammasome Activation. [PDF]

Stem Cell Rev Rep
Adamiak M, Thetchinamoorthy K, Wierzbicka D, Kazek M, Waraksa-Zasada E, Lukomska A, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M, Ratajczak MZ.   +9 more
europepmc   +1 more source

Endolysosomal Impact of Elevated Ceramide Levels Revealed by Optical and Ultrastructural Nanoprobing. [PDF]

ACS Nano
Feng Y, Gärber F, Saied EM, Singh H, Spedalieri C, Werner S, Pratsch C, Arenz C, Seifert S, Kneipp J.   +9 more
europepmc   +1 more source

Real-life impacts of olipudase alfa: experiences of adults receiving enzyme replacement therapy for acid sphingomyelinase deficiency-results from an international survey study. [PDF]

Orphanet J Rare Dis
Morsy AS, Mbua S, Mathieson T, Hopkin J, Bolton S.   +4 more
europepmc   +1 more source

Unexplained splenomegaly as a diagnostic marker for a rare but severe disease with an innovative and highly effective new treatment option: A case report. [PDF]

Mol Genet Metab Rep
Van Baelen A, Verhulst S, Eyskens F.
europepmc   +1 more source

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1. [PDF]

Front Immunol
Hu Z, Abdelrahman H, Elwy A, Kuang F, Dhiman S, Ali S, Marson M, Holnsteiner L, Hamdan TA, Friebus-Kardash J, Wiebeck E, Hansen W, Scheu S, Gulbins E, Lang PA, Lang KS, Lang J.   +16 more
europepmc   +1 more source

Mapping Lysosomal Storage Disorders with Neurological Features by Cellular Pathways: Towards Precision Medicine. [PDF]

Curr Issues Mol Biol
Makridou A, Sintou E, Chatzianagnosti S, Gargani S, Manthou ME, Dermitzakis I, Theotokis P.   +6 more
europepmc   +1 more source

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Production and purification of tag-free recombinant human acid sphingomyelinase in Nicotiana benthamiana

Plant Cell Reports
Tag-free, functional human acid sphingomyelinase was successfully produced in a plant-based system. Apoplastic wash fluid extraction improved downstream processing, and a two-step ion exchange chromatography enabled purification of plant-derived ASM.
Kulachatr Panyawechamontri, Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama   +3 more
openaire   +4 more sources

Inhibition of acid sphingomyelinase increases regulatory T cells in humans.

Brain Communications, 2021
Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been shown to increase Foxp3\(^+\) regulatory T-cell frequencies among CD4\(^+\) T cells in mice.
Jürgen Schneider-Schaulies, Bernard Vanhove, Fabian Schumacher   +2 more
exaly   +2 more sources