Results 121 to 130 of about 6,914 (144)

Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization

Journal of Biotechnology, 1998
Biochemical and structural studies on human acid sphingomyelinase (haSMase) depend on the access to homogeneous biologically active enzyme. Due to the low abundance of native haSMase (n-haSMase) in human tissue, conventional purification strategies are not suitable for the isolation of preparative amounts of the enzyme.
O, Bartelsen, S, Lansmann, M, Nettersheim, T, Lemm, K, Ferlinz, K, Sandhoff   +5 more
openaire   +4 more sources

Hepatic pathology of acid sphingomyelinase deficiency: Clearance of sphingomyelin with recombinant human acid sphingomyelinase administration is associated with improvement in pro-atherogenic lipid profiles

Molecular Genetics and Metabolism, 2015
Beth Thurberg, Melissa P. Wasserstein, Simon A. Jones, Thomas Schiano, Gerald F. Cox, Ana Cristina Puga   +5 more
openaire   +1 more source

An open-label, multicenter, ascending dose study of the tolerability and safety of recombinant human acid sphingomyelinase (rhASM) in patients with ASM deficiency (ASMD)

Molecular Genetics and Metabolism, 2014
Simon Jones, Melissa Wasserstein, Handrean Soran, Catherine Breen, Beth Thurberg, Kerry Culm-Merdek, Natalie Lippa, Brenda Pimlott, Andrew Cunningham   +8 more
openaire   +1 more source

A phase 1 trial of recombinant human acid Sphingomyelinase (rhASM) Enzyme replacement therapy in adults with Non-Neuronopathic ASM deficiency (ASMD Niemann-Pick B)

Molecular Genetics and Metabolism, 2011
Margaret McGovern, Melissa Wasserstein, Brian Kirmse, Lane Duvall, Thomas Schiano, Beth Thurberg, Susan Richards, Gerald Cox   +7 more
openaire   +1 more source

An open-label, multicenter, ascending-repeat-dose study of the tolerability and safety of recombinant human acid sphingomyelinase (rhASM) in patients with ASM deficiency (ASMD)

Molecular Genetics and Metabolism, 2015
Melissa P. Wasserstein, Simon A. Jones, Handrean Soran, George Diaz, Natalie Lippa, Beth L. Thurberg, Kerry Culm-Merdek, Elias Shamiyeh, Haig Inguilizian, Ana Cristina Puga   +9 more
openaire   +1 more source

[16] Purification and characterization of recombinant human acid sphingomyelinase expressed in insect Sf21 cells

2000
S. Lansmann, O. Bartelsen, K. Sandhoff
openaire   +1 more source

Cervical cancer prevention and control in women living with human immunodeficiency virus

Ca-A Cancer Journal for Clinicians, 2021
Philip E Castle, Vikrant V Sahasrabuddhe
exaly  

Production and purification of tag-free recombinant human acid sphingomyelinase in Nicotiana benthamiana

Plant Cell Reports
Kulachatr Panyawechamontri, Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama   +3 more
openaire   +1 more source

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

Cell Reports Medicine, 2020
Alexander Carpinteiro, Markus Hoffmann, Georg Kochs   +2 more
exaly