The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
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Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells [PDF]
, 2018 The mechanisms of Pb(II) toxicity have been studied in human red blood cells using confocal microscopy, immunolabeling, fluorescence-activated cell sorting and atomic force microscopy. The process follows a sequence of events, starting with calcium entry,
A Bateman +80 more
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Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets [PDF]
, 2015 The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune
Chen, Limin +12 more
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Proteomic profiling reveals the transglutaminase-2 externalization pathway in kidneys after unilateral ureteric obstruction [PDF]
, 2018 Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion.
A. +22 more
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Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. [PDF]
, 2018 Endogenous sphingolipids (ceramide) and related synthetic molecules (FTY720, SH-BC-893) reduce nutrient access by decreasing cell surface expression of a subset of nutrient transporter proteins.
Corrales, Dania Virginia +12 more
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Influenza virus morphogenesis and budding. [PDF]
, 2009 Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to Orthomyxoviridae family. Each virion consists of three major sub-viral components, namely (i) a viral envelope decorated with three transmembrane proteins ...
Balogun, Rilwan A +4 more
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Influence of pH control in the formation of inclusion bodies during production of recombinant sphingomyelinase-D in Escherichia coli [PDF]
, 2014 Alejandro Alagón +8 more
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La apolipoproteína D ralentiza el proceso de neurodegeneración en la enfermedad de Niemann-Pick tipo A [PDF]
, 2019 La enfermedad de Niemann-Pick tipo A (NPA) es una enfermedad de depósito lisosomal de herencia autosómico-recesiva. En ella, la deficiencia de esfingomielinasa ácida provoca un gran acúmulo de esfingomielina en las membranas celulares. Esto conduce a una
Fadrique Rojo, Cristian
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Interaction of mycobacterium tuberculosis with the host cells: a focus in the molecular mechanism involved in trafficking and autophagy [PDF]
, 2018 Tuberculosis (TB) is an ancient disease remaining a serious health threat worldwide. It is caused by Mycobacterium tuberculosis (Mtb), an acid-fast bacilli, non-sporulated, slow-growing, immobile and aerobic.
Colombo, Maria Isabel +2 more
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Chemical approaches to sphingolipid research [PDF]
, 2015 Podeu consultar el llibre complet a: http://hdl.handle.net/2445 ...
Abad Saiz, José Luis +3 more
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