Results 11 to 20 of about 6,420,190 (386)

Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk

Cancer Cell International, 2022
As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman, Rana Vafaei, Mitra Samadi, Mohammad Hossein Kazemi, Aysooda Hosseinzadeh, Parnaz Merikhian, Shima Moradi-Kalbolandi, Mohammad Reza Eisavand, Houra Dinvari, Leila Farahmand   +9 more
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MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy

Cancer Cell International, 2022
Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC).
Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand, Leila Farahmand   +4 more
doaj   +1 more source

Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo

Journal of Biological Engineering, 2021
Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells.
Mitra Samadi, Keivan Majidzadeh-A, Malihe Salehi, Neda Jalili, Zeinab Noorinejad, Marjan Mosayebzadeh, Ahad Muhammadnejad, Azadeh Sharif khatibi, Shima Moradi-Kalbolandi, Leila Farahmand   +9 more
doaj   +1 more source

Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Cancer Cell International, 2022
Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors ...
Rana Vafaei, Mitra Samadi, Aysooda Hosseinzadeh, Khadijeh Barzaman, MohammadReza Esmailinejad, Zohreh Khaki, Leila Farahmand   +6 more
doaj   +1 more source

Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors

Molecular Oncology, 2022
Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis.
Parnaz Merikhian, Behrad Darvishi, Neda Jalili, Mohammad Reza Esmailinejad, Azadeh Sharif Khatibi, Shima Moradi Kalbolandi, Malihe Salehi, Marjan Mosayebzadeh, Mahdieh Shokrollahi Barough, Keivan Majidzadeh‐A, Fatemeh Yadegari, Fatemeh Rahbarizadeh, Leila Farahmand   +12 more
doaj   +1 more source

Yeast synthetic biology for designed cell factories producing secretory recombinant proteins.

FEMS Yeast Research, 2020
Yeasts are prominent hosts for the production of recombinant proteins from industrial enzymes to therapeutic proteins. Particularly, the similarity of protein secretion pathways between these unicellular eukaryotic microorganisms and higher eukaryotic ...
Eun Jung Thak, S. Yoo, H. Moon, H. Kang
semanticscholar   +1 more source

Crosstalk between MUC1 and VEGF in angiogenesis and metastasis: a review highlighting roles of the MUC1 with an emphasis on metastatic and angiogenic signaling

Cancer Cell International, 2021
VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis.
Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand, Leila Farahmand   +3 more
doaj   +1 more source

The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies

Cancer Cell International, 2023
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth, migration, death, and metastasis.
Bahareh Hassani, Zeinab Attar, Negar Firouzabadi   +2 more
doaj   +1 more source

Roles of the AtErcc1 protein in recombination [PDF]

The Plant Journal, 2004
SummaryAtercc1, the recently characterized Arabidopsis homologue of the Ercc1 (Rad10) protein, is a key component of nucleotide excision repair as part of a structure‐specific endonuclease which cleaves 5′ to UV photoproducts in DNA. This endonuclease also acts in removing overhanging non‐homologous DNA ‘tails’ in synapsed recombination intermediates ...
Dubest, Sandra, Gallego, Maria, White, Charles   +2 more
openaire   +6 more sources

Recombination of Fragmented Proteins [PDF]

Chemistry & Biology, 2004
Directed evolution is a powerful method for generating novel molecules with desirable properties. In developing a new sensor to screen for protein-protein interactions, Tafelmeyer et al. report a clever strategy to evolve heterodimeric "split proteins" from a monomer in this issue of Chemistry & Biology.
openaire   +3 more sources