Results 11 to 20 of about 1,100,263 (385)

Recombinant proteins in plants. [PDF]

BMC Proceedings, 2014
Edição do Congress of the Brazilian Biotechnology Society, Florianópolis ...
ANDREW, S., ARAUJO, A. C. G. de, BARRY, O., BRIGIDO, M., CUNHA, N., FONTES, A., LACORTE, C. C., MICHAEL, W., MURAD, A. M., OTAVIA, C., RECH FILHO, E. L., VIANNA, G. R.   +11 more
core   +5 more sources

Producing recombinant proteins in Vibrio natriegens [PDF]

Microbial Cell Factories
The diversity of chemical and structural attributes of proteins makes it inherently difficult to produce a wide range of proteins in a single recombinant protein production system.
Matthew Smith, José Sánchez Hernández, Simon Messing, Nitya Ramakrishnan, Brianna Higgins, Jennifer Mehalko, Shelley Perkins, Vanessa E. Wall, Carissa Grose, Peter H. Frank, Julia Cregger, Phuong Vi Le, Adam Johnson, Mukul Sherekar, Morgan Pagonis, Matt Drew, Min Hong, Stephanie R. T. Widmeyer, John-Paul Denson, Kelly Snead, Ivy Poon, Timothy Waybright, Allison Champagne, Dominic Esposito, Jane Jones, Troy Taylor, William Gillette   +26 more
doaj   +2 more sources

Synthesized Anti-HER2 Trastuzumab-MCC-DM1 Conjugate: An Evaluation of Efficacy and Cytotoxicity [PDF]

Iranian Journal of Immunology, 2023
Background: Trastuzumab is a humanized monoclonal antibody that targets site-specifically human epidermal growth factor-2 receptor (HER2) cell surface antigen overexpressed in approximately 20% of human breast carcinomas. Despite its positive therapeutic
Soodabeh Shafiee, Roya Mirzaei, Malihe Salehi, Neda Jalili, Amir Taheri, Leila Farahmand   +5 more
doaj   +1 more source

Engineering and production of recombinant bovine pancreatic ribonuclease enzyme (RNase A) as a potential therapeutic [PDF]

مجله بیوتکنولوژی کشاورزی, 2021
Objective  Immunotoxins are one of the most promising ways in therapeutic fields, specially cancer therapy which have a unique toxin-antibody structure, and kill the cancer cell by passing through the cell membrane and entering the target cell.
Masoume Vakili-Azghandi, Mohammadreza Nassiri, Shahrokh Ghovvati, Ali Javadmanesh   +3 more
doaj   +1 more source

Recombinant Protein Stability in Cyanobacteria [PDF]

ACS Synthetic Biology, 2021
The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize and efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier to the overexpression of recombinant proteins in most expression systems. A notable exception is the overexpression in E.
Xianan Zhang, Nico Betterle, Diego Hidalgo Martinez, Anastasios Melis   +3 more
openaire   +5 more sources

Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk

Cancer Cell International, 2022
As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman, Rana Vafaei, Mitra Samadi, Mohammad Hossein Kazemi, Aysooda Hosseinzadeh, Parnaz Merikhian, Shima Moradi-Kalbolandi, Mohammad Reza Eisavand, Houra Dinvari, Leila Farahmand   +9 more
doaj   +1 more source

MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy

Cancer Cell International, 2022
Although resistance is its major obstacle in cancer therapy, trastuzumab is the most successful agent in treating epidermal growth factor receptor 2 positive (HER2 +) breast cancer (BC).
Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand, Leila Farahmand   +4 more
doaj   +1 more source

Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo

Journal of Biological Engineering, 2021
Development of engineered non-pathogenic bacteria, capable of expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells.
Mitra Samadi, Keivan Majidzadeh-A, Malihe Salehi, Neda Jalili, Zeinab Noorinejad, Marjan Mosayebzadeh, Ahad Muhammadnejad, Azadeh Sharif khatibi, Shima Moradi-Kalbolandi, Leila Farahmand   +9 more
doaj   +1 more source

Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Cancer Cell International, 2022
Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors ...
Rana Vafaei, Mitra Samadi, Aysooda Hosseinzadeh, Khadijeh Barzaman, MohammadReza Esmailinejad, Zohreh Khaki, Leila Farahmand   +6 more
doaj   +1 more source

Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors

Molecular Oncology, 2022
Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis.
Parnaz Merikhian, Behrad Darvishi, Neda Jalili, Mohammad Reza Esmailinejad, Azadeh Sharif Khatibi, Shima Moradi Kalbolandi, Malihe Salehi, Marjan Mosayebzadeh, Mahdieh Shokrollahi Barough, Keivan Majidzadeh‐A, Fatemeh Yadegari, Fatemeh Rahbarizadeh, Leila Farahmand   +12 more
doaj   +1 more source